• Gene Name：
• TACC1

• Human Gene Id：
• 6867

• Human Swiss Prot No：
• O75410

• Mouse Swiss Prot No：
• Q6Y685

• Storage Stability：
• 2-8°C/6 months

• Other Name：
• Transforming acidic coiled-coil-containing protein 1 (Gastric cancer antigen Ga55) (Taxin-1)

• Detection Method：
• Colorimetric

• Background：
• alternative products:Additional isoforms seem to exist,developmental stage:Expressed at high level during early embryogenesis.,function:Likely involved in the processes that promote cell division prior to the formation of differentiated tissues.,miscellaneous:Down-regulated in a subset of cases of breast cancer.,PTM:Isoform 1 is heavily phosphorylated; isoform 6 is not. Phosphorylated upon DNA damage, probably by ATM or ATR.,similarity:Belongs to the TACC family.,similarity:Contains 2 SPAZ (Ser/Pro-rich AZU-1) domains.,subcellular location:Nucleus during interphase. Weakly concentrated at centrosomes during mitosis.,subunit:Interacts with KIAA0097/CH-TOG and with the oncogenic transcription factor YEATS4. Interacts with the Aurora kinases A and B (STK6 and AURKB). Interacts with LSM7, TDRD7 and SNRPG. Interacts with GCN5L2 and PCAF.,tissue specificity:Isoform 1, isoform 3 and isoform 5 are ubiquitous. Isoform 2 is strongly expressed in the brain, weakly detectable in lung and colon, and overexpressed in gastric cancer. Isoform 4 is not detected in normal tissues, but strong expression was found in gastric cancer tissues.,

• Function：
• cell cycle, cell division,

• Subcellular Location：
• Cytoplasm . Nucleus . Cytoplasm, cytoskeleton, microtubule organizing center, centrosome . Midbody . Nucleus during interphase. Weakly concentrated at centrosomes during mitosis and colocalizes with AURKC at the midbody during cytokinesis. .; [Isoform 5]: Membrane ; Lipid-anchor .; [Isoform 10]: Cytoplasm .

• Expression：
• Isoform 1, isoform 3 and isoform 5 are ubiquitous. Isoform 2 is strongly expressed in the brain, weakly detectable in lung and colon, and overexpressed in gastric cancer. Isoform 4 is not detected in normal tissues, but strong expression was found in gastric cancer tissues. Down-regulated in a subset of cases of breast cancer.

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