Total UBE1L Cell-Based Colorimetric ELISA Kit
- Catalog No.:KA3425C
- Applications:ELISA
- Reactivity:Human
- Gene Name:
- UBA7
- Human Gene Id:
- 7318
- Human Swiss Prot No:
- P41226
- Storage Stability:
- 2-8°C/6 months
- Other Name:
- Ubiquitin-like modifier-activating enzyme 7 (Ubiquitin-activating enzyme 7) (D8) (Ubiquitin-activating enzyme E1 homolog)
- Detection Method:
- Colorimetric
- Background:
- function:Activates ubiquitin by first adenylating with ATP its C-terminal glycine residue and thereafter linking this residue to the side chain of a cysteine residue in E1, yielding an ubiquitin-E1 thioester and free AMP.,miscellaneous:There are two active sites within the E1 molecule, allowing it to accommodate two ubiquitin moieties at a time, with a new ubiquitin forming an adenylate intermediate as the previous one is transferred to the thiol site.,pathway:Protein modification; protein ubiquitination.,similarity:Belongs to the ubiquitin-activating E1 family.,subunit:Monomer (By similarity). Binds and is involved in the conjugation of G1P2/ISG15.,tissue specificity:Expressed in a variety of normal and tumor cell types, but is reduced in lung cancer cell lines.,
- Function:
- proteolysis, macromolecule catabolic process, modification-dependent protein catabolic process, protein catabolic process, ISG15-protein conjugation, modification-dependent macromolecule catabolic process, cellular protein catabolic process, cellular macromolecule catabolic process, proteolysis involved in cellular protein catabolic process,
- Expression:
- Expressed in a variety of normal and tumor cell types, but is reduced in lung cancer cell lines.
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