Total NUB1 Cell-Based Colorimetric ELISA Kit
- Catalog No.:KA3409C
- Applications:ELISA
- Reactivity:Human;Mouse
- Gene Name:
- NUB1
- Human Gene Id:
- 51667
- Human Swiss Prot No:
- Q9Y5A7
- Mouse Swiss Prot No:
- P54729
- Storage Stability:
- 2-8°C/6 months
- Other Name:
- NEDD8 ultimate buster 1 (Negative regulator of ubiquitin-like proteins 1) (Renal carcinoma antigen NY-REN-18)
- Detection Method:
- Colorimetric
- Background:
- function:Specific down-regulator of the NEDD8 conjugation system. Recruits NEDD8 and its conjugates to the proteasome for degradation. Isoform 1 promotes the degradation of NEDD8 more efficiently than isoform 2.,induction:By beta and gamma interferons.,similarity:Contains 3 UBA domains.,subcellular location:Predominantly nuclear.,subunit:Directly interacts with NEDD8 and PSMD4/S5a, a member of the regulatory subunit of the 26S proteasome. Isoform 1 binds to NEDD8 more efficiently than isoform 2. Interacts with AIPL1.,tissue specificity:Widely expressed with lowest expression in the pancreas for isoform 1 and in leukocytes, liver, prostate and skeletal muscle for isoform 2.,
- Subcellular Location:
- Nucleus . Predominantly nuclear.
- Expression:
- Widely expressed with lowest expression in the pancreas for isoform 1 and in leukocytes, liver, prostate and skeletal muscle for isoform 2.
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