• Gene Name：
• TGM2

• Human Gene Id：
• 7052

• Human Swiss Prot No：
• P21980

• Mouse Swiss Prot No：
• P21981

• Storage Stability：
• 2-8°C/6 months

• Other Name：
• Protein-glutamine gamma-glutamyltransferase 2 (EC 2.3.2.13) (Tissue transglutaminase) (Transglutaminase C) (TG(C)) (TGC) (TGase C) (Transglutaminase H) (TGase H) (Transglutaminase-2) (TGase-2)

• Detection Method：
• Colorimetric

• Background：
• catalytic activity:Protein glutamine + alkylamine = protein N(5)-alkylglutamine + NH(3).,cofactor:Binds 1 calcium ion per subunit.,disease:Defects in TGM2 are involved in early-onset diabetes type 2.,function:Catalyzes the cross-linking of proteins and the conjugation of polyamines to proteins.,induction:By retinoic acid.,online information:Tissue transglutaminase entry,similarity:Belongs to the transglutaminase superfamily. Transglutaminase family.,subunit:Monomer.,

• Function：
• blood vessel development, vasculature development, blood vessel remodeling, protein complex assembly, cellular ion homeostasis, cellular calcium ion homeostasis, cellular metal ion homeostasis, anti-apoptosis, induction of apoptosis,cell surface receptor linked signal transduction, G-protein coupled receptor protein signaling pathway, activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger,activation of phospholipase C activity, elevation of cytosolic calcium ion concentration, intracellular signaling cascade,cell death, positive regulation of cell proliferation, positive regulation of signal transduction, regulation of phospholipase activity, positive regulation of phospholipase activity, regulation of protein kinase cascade, positive regulation of cell communication, positive regulation of protein kinase cascade, po

• Subcellular Location：
• Cytoplasm, cytosol . Nucleus . Chromosome . Secreted, extracellular space, extracellular matrix . Cell membrane . Mitochondrion . Mainly localizes to the cytosol (PubMed:9575137). Present at much lower level in the nucleus and chromatin (PubMed:9575137). Also secreted via a non-classical secretion pathway to the extracellular matrix (PubMed:27270573). .; [Isoform 2]: Cytoplasm, perinuclear region .

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