Total Oct-3/4 Cell-Based Colorimetric ELISA Kit

  • Catalog No.：KA3343C
  • Applications：ELISA
  • Reactivity：Human;Mouse;Rat
    • Gene Name：
    • POU5F1
    • Human Gene Id：
    • 5460
    • Human Swiss Prot No：
    • Q01860
    • Mouse Swiss Prot No：
    • P20263
    • Storage Stability：
    • 2-8°C/6 months
    • Other Name：
    • POU domain, class 5, transcription factor 1 (Octamer-binding protein 3) (Oct-3) (Octamer-binding protein 4) (Oct-4) (Octamer-binding transcription factor 3) (OTF-3)
    • Detection Method：
    • Colorimetric
    • Background：
    • function:Transcription factor that binds to the octamer motif (5'-ATTTGCAT-3'). Forms a trimeric complex with SOX2 on DNA and controls the expression of a number of genes involved in embryonic development such as YES1, FGF4, UTF1 and ZFP206. Critical for early embryogenesis and for embryonic stem cell pluripotency.,miscellaneous:Several pseudogenes of POU5F1 have been described on chromosomes 1, 3, 8, 10 and 12. 2 of them, localized in chromosomes 8 and 10, are transcribed in cancer tissues but not in normal ones and may be involved in the regulation of POU5F1 gene activity in carcinogenesis.,online information:Oct-4 entry,PTM:Sumoylation enhances the protein stability, DNA binding and transactivation activity. Sumoylation is required for enhanced YES1 expression.,similarity:Belongs to the POU transcription factor family. Class-5 subfamily.,similarity:Contains 1 homeobox DNA-binding domain.,similarity:Contains 1 POU-specific domain.,subcellular location:Expressed in a diffuse and slightly punctuate pattern.,subunit:Interacts with UBE2I.,tissue specificity:Expressed in developing brain. Highest levels found in specific cell layers of the cortex, the olfactory bulb, the hippocampus and the cerebellum. Low levels of expression in adult tissues.,
    • Function：
    • transcription, regulation of transcription, DNA-dependent, regulation of transcription, regulation of RNA metabolic process,
    • Subcellular Location：
    • Cytoplasm. Nucleus. Expressed in a diffuse and slightly punctuate pattern. Colocalizes with MAPK8 and MAPK9 in the nucleus. .
    • Expression：
    • Expressed in developing brain. Highest levels found in specific cell layers of the cortex, the olfactory bulb, the hippocampus and the cerebellum. Low levels of expression in adult tissues.

    Attributes

    • Code：
    • KA3343C
    • Size
    • 96 / well
    • Price$：
    • 330
    • Delivery：
    • 2024-12-07
    Order

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