• Gene Name：
• MMP11

• Human Gene Id：
• 4320

• Human Swiss Prot No：
• P24347

• Mouse Swiss Prot No：
• Q02853

• Rat Swiss Prot No：
• Q499S5

• Storage Stability：
• 2-8°C/6 months

• Other Name：
• Stromelysin-3 (SL-3) (ST3) (EC 3.4.24.-) (Matrix metalloproteinase-11) (MMP-11)

• Detection Method：
• Colorimetric

• Background：
• cofactor:Binds 1 calcium ion per subunit.,cofactor:Binds 2 zinc ions per subunit.,domain:The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting the enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the enzyme.,function:May play an important role in the progression of epithelial malignancies.,PTM:The precursor is cleaved by a furin endopeptidase.,similarity:Belongs to the peptidase M10A family.,similarity:Contains 4 hemopexin-like domains.,tissue specificity:Specifically expressed in stromal cells of breast carcinomas.,

• Function：
• proteolysis, collagen catabolic process, collagen metabolic process, multicellular organismal metabolic process,multicellular organismal catabolic process, multicellular organismal macromolecule metabolic process,

• Subcellular Location：
• Secreted, extracellular space, extracellular matrix .

• Expression：
• Specifically expressed in stromal cells of breast carcinomas.

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