Total MMP-11 Cell-Based Colorimetric ELISA Kit
- Catalog No.:KA3324C
- Applications:ELISA
- Reactivity:Human;Mouse;Rat
- Gene Name:
- MMP11
- Human Gene Id:
- 4320
- Human Swiss Prot No:
- P24347
- Mouse Swiss Prot No:
- Q02853
- Rat Swiss Prot No:
- Q499S5
- Storage Stability:
- 2-8°C/6 months
- Other Name:
- Stromelysin-3 (SL-3) (ST3) (EC 3.4.24.-) (Matrix metalloproteinase-11) (MMP-11)
- Detection Method:
- Colorimetric
- Background:
- cofactor:Binds 1 calcium ion per subunit.,cofactor:Binds 2 zinc ions per subunit.,domain:The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting the enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the enzyme.,function:May play an important role in the progression of epithelial malignancies.,PTM:The precursor is cleaved by a furin endopeptidase.,similarity:Belongs to the peptidase M10A family.,similarity:Contains 4 hemopexin-like domains.,tissue specificity:Specifically expressed in stromal cells of breast carcinomas.,
- Function:
- proteolysis, collagen catabolic process, collagen metabolic process, multicellular organismal metabolic process,multicellular organismal catabolic process, multicellular organismal macromolecule metabolic process,
- Subcellular Location:
- Secreted, extracellular space, extracellular matrix .
- Expression:
- Specifically expressed in stromal cells of breast carcinomas.
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