• Gene Name：
• MYC

• Human Gene Id：
• 4609

• Human Swiss Prot No：
• P01106

• Mouse Swiss Prot No：
• P01108

• Rat Swiss Prot No：
• P09416

• Storage Stability：
• 2-8°C/6 months

• Other Name：
• Myc proto-oncogene protein (Class E basic helix-loop-helix protein 39) (bHLHe39) (Proto-oncogene c-Myc) (Transcription factor p64)

• Detection Method：
• Colorimetric

• Background：
• disease:A chromosomal aberration involving MYC may be a cause of a form of B-cell chronic lymphocytic leukemia. Translocation t(8;12)(q24;q22) with BTG1.,disease:Overexpression of MYC is implicated in the etiology of a variety of hematopoietic tumors.,function:Participates in the regulation of gene transcription. Binds DNA both in a non-specific manner and also specifically to recognizes the core sequence 5'-CAC[GA]TG-3'. Seems to activate the transcription of growth-related genes.,online information:Myc entry,PTM:Phosphorylated by PRKDC.,similarity:Contains 1 basic helix-loop-helix (bHLH) domain.,subunit:Efficient DNA binding requires dimerization with another bHLH protein. Binds DNA as a heterodimer with MAX. Interacts with TAF1C and SPAG9. Interacts with PARP10. Interacts with KDM5A and KDM5B.,

• Function：
• DNA catabolic process, endonucleolytic, skeletal system development, B cell apoptosis, release of cytochrome c from mitochondria, regulation of B cell apoptosis, positive regulation of B cell apoptosis, monosaccharide metabolic process,glucose metabolic process, DNA metabolic process, DNA catabolic process, DNA fragmentation involved in apoptosis,transcription, transcription, DNA-dependent, transcription initiation, regulation of transcription, DNA-dependent,regulation of transcription from RNA polymerase II promoter, transcription from RNA polymerase II promoter, protein complex assembly, cellular ion homeostasis, cellular iron ion homeostasis, apoptosis, anti-apoptosis, induction of apoptosis, activation of caspase activity, cell structure disassembly during apoptosis, nucleus organization,mitochondrion organization, cell cycle, cell cycle arrest, regulation of mitotic cell cycle, sens

• Subcellular Location：
• Nucleus, nucleoplasm . Nucleus, nucleolus .

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