Total Caveolin-1 Cell-Based Colorimetric ELISA Kit

  • Catalog No.：KA3065C
  • Applications：ELISA
  • Reactivity：Human;Mouse;Rat
    • Gene Name：
    • CAV1
    • Human Gene Id：
    • 857
    • Human Swiss Prot No：
    • Q03135
    • Mouse Swiss Prot No：
    • P49817
    • Storage Stability：
    • 2-8°C/6 months
    • Other Name：
    • Caveolin-1
    • Detection Method：
    • Colorimetric
    • Background：
    • disease:Defects in CAV1 are the cause of congenital generalized lipodystrophy type 3 (CGL3) [MIM:612526]; also called Berardinelli-Seip congenital lipodystrophy type 3 (BSCL3). Congenital generalized lipodystrophies are autosomal recessive disorders characterized by a near absence of adipose tissue, extreme insulin resistance, hypertriglyceridemia, hepatic steatosis and early onset of diabetes.,function:May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity.,online information:Caveolin entry,PTM:The initiator methionine for isoform Beta is removed during or just after translation. The new N-terminal amino acid is then N-acetylated.,similarity:Belongs to the caveolin family.,subcellular location:Potential hairpin-like structure in the membrane. Membrane protein of caveolae.,subunit:Homooligomer. Interacts with GLIPR2, NOSTRIN, SNAP25 and syntaxin. Interacts with rotavirus A NSP4.,tissue specificity:In muscle and lung, less so in liver, brain and kidney.,
    • Function：
    • MAPKKK cascade, inactivation of MAPK activity, microtubule cytoskeleton organization, blood vessel development,vasculogenesis, response to hypoxia, membrane raft formation, regulation of protein amino acid phosphorylation,negative regulation of protein amino acid phosphorylation, positive regulation of protein amino acid phosphorylation,regulation of endothelial cell proliferation, negative regulation of endothelial cell proliferation, vasculature development, regulation of cytokine-mediated signaling pathway, negative regulation of cytokine-mediated signaling pathway, circulatory system process, vascular process in circulatory system, protein complex assembly, negative regulation of protein kinase activity, neutral lipid metabolic process, acylglycerol metabolic process, triglyceride metabolic process, glycerol ether metabolic process, ion transport, cation transport, calcium ion transp
    • Subcellular Location：
    • Golgi apparatus membrane; Peripheral membrane protein. Cell membrane; Peripheral membrane protein. Membrane, caveola ; Peripheral membrane protein. Membrane raft . Golgi apparatus, trans-Golgi network . Colocalized with DPP4 in membrane rafts. Potential hairpin-like structure in the membrane. Membrane protein of caveolae.
    • Expression：
    • Skeletal muscle, liver, stomach, lung, kidney and heart (at protein level). Expressed in the brain.

    Attributes

    • Code：
    • KA3065C
    • Size
    • 96 / well
    • Price$：
    • 330
    • Delivery：
    • 2024-08-03
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