Phospho HDAC2 (S394) Cell-Based Colorimetric ELISA Kit

  • Catalog No.：KA1579C
  • Applications：ELISA
  • Reactivity：Human;Mouse;Rat
    • Gene Name：
    • HDAC2
    • Human Gene Id：
    • 3066
    • Human Swiss Prot No：
    • Q92769
    • Mouse Swiss Prot No：
    • P70288
    • Storage Stability：
    • 2-8°C/6 months
    • Other Name：
    • Histone deacetylase 2 (HD2) (EC 3.5.1.98)
    • Detection Method：
    • Colorimetric
    • Background：
    • catalytic activity:Hydrolysis of an N(6)-acetyl-lysine residue of a histone to yield a deacetylated histone.,function:Forms transcriptional repressor complexes by associating with MAD, SIN3, YY1 and N-COR. Interacts in the late S-phase of DNA-replication with DNMT1 in the other transcriptional repressor complex composed of DNMT1, DMAP1, PCNA, CAF1.,function:Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes.,sequence caution:Intron retention.,similarity:Belongs to the histone deacetylase family. Type 1 subfamily.,subunit:Interacts with the non-histone region of H2AFY (By similarity). Part of the core histone deacetylase (HDAC) complex composed of HDAC1, HDAC2, RBBP4 and RBBP7. The core complex associates with MTA2, MBD3, MTA1L1, CHD3 and CHD4 to form the nucleosome remodeling and histone deacetylation (NuRD) complex, or with SIN3, SAP18 and SAP30 to form the SIN3 HDAC complex. Component of a BHC histone deacetylase complex that contains HDAC1, HDAC2, HMG20B/BRAF35, AOF2/LSD1, RCOR1/CoREST and PHF21A/BHC80. The BHC complex may also contain ZMYM2, ZNF217, ZMYM3, GSE1 and GTF2I. Part of a complex containing the core histones H2A, H2B, H3 and H4, DEK and unphosphorylated DAXX. Part of a complex containing ATR and CHD4. Forms a heterologous complex at least with YY1. Interacts with ATR, DNMT1, MINT, HDAC7, HDAC10, HCFC1, NRIP1, MJD2A/JHDM3A, PRDM6, SAP30, SETDB1 and SUV39H1. Interacts with the non-histone region of H2AFY. Interacts with PELP1. Component of a mSin3A corepressor complex that contains SIN3A, SAP130, SUDS3/SAP45, ARID4B/SAP180, HDAC1 and HDAC2. Interacts with CBFA2T3. Interacts with SAP30L.,tissue specificity:Widely expressed; lower levels in brain and lung.,
    • Function：
    • negative regulation of transcription from RNA polymerase II promoter, chromatin organization, chromatin remodeling,chromatin silencing, maintenance of chromatin silencing, transcription, regulation of transcription, DNA-dependent,regulation of transcription from RNA polymerase II promoter, protein amino acid deacetylation, positive regulation of cell proliferation, response to temperature stimulus, response to heat, response to abiotic stimulus, negative regulation of biosynthetic process, positive regulation of biosynthetic process, response to organic substance,regulation of specific transcription from RNA polymerase II promoter, positive regulation of specific transcription from RNA polymerase II promoter, negative regulation of specific transcription from RNA polymerase II promoter, positive regulation of macromolecule biosynthetic process, negative regulation of macromolecule biosyn
    • Subcellular Location：
    • Nucleus . Cytoplasm .
    • Expression：
    • Widely expressed; lower levels in brain and lung.

    Attributes

    • Code：
    • KA1579C
    • Size
    • 96 / well
    • Price$：
    • 470
    • Delivery：
    • 2024-08-01
    Order

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