• Gene Name：
• CFL1

• Human Gene Id：
• 1072

• Human Swiss Prot No：
• P23528

• Mouse Swiss Prot No：
• P18760

• Rat Swiss Prot No：
• P45592

• Storage Stability：
• 2-8°C/6 months

• Other Name：
• Cofilin-1 (18 kDa phosphoprotein) (p18) (Cofilin, non-muscle isoform)

• Detection Method：
• Colorimetric

• Background：
• function:Controls reversibly actin polymerization and depolymerization in a pH-sensitive manner. It has the ability to bind G- and F-actin in a 1:1 ratio of cofilin to actin. It is the major component of intranuclear and cytoplasmic actin rods.,online information:Cofilin entry,PTM:Phosphorylated on Ser-3 in resting cells.,similarity:Belongs to the actin-binding proteins ADF family.,similarity:Contains 1 ADF-H domain.,subcellular location:Almost completely in nucleus in cells exposed to heat shock or 10% dimethyl sulfoxide.,tissue specificity:Widely distributed in various tissues.,

• Function：
• cell morphogenesis, cytokinesis, response to acid, ameboidal cell migration, neural crest cell migration, embryonic epithelial tube formation, neural plate morphogenesis, neural plate development, neural tube formation, neural fold formation, morphogenesis of an epithelium, protein amino acid phosphorylation, phosphorus metabolic process,phosphate metabolic process, anti-apoptosis, cell motion, cytoskeleton organization, actin filament organization,establishment or maintenance of cell polarity, intracellular signaling cascade, small GTPase mediated signal transduction, Ras protein signal transduction, Rho protein signal transduction, regulation of actin polymerization or depolymerization, response to endogenous stimulus, embryonic development ending in birth or egg hatching,response to organic substance, response to organic nitrogen, positive regulation of organelle organization, regulat

• Subcellular Location：
• Nucleus matrix . Cytoplasm, cytoskeleton . Cell projection, ruffle membrane ; Peripheral membrane protein ; Cytoplasmic side . Cell projection, lamellipodium membrane ; Peripheral membrane protein ; Cytoplasmic side . Cell projection, lamellipodium . Cell projection, growth cone . Cell projection, axon . Colocalizes with the actin cytoskeleton in membrane ruffles and lamellipodia. Detected at the cleavage furrow and contractile ring during cytokinesis. Almost completely in nucleus in cells exposed to heat shock or 10% dimethyl sulfoxide.

• Expression：
• Widely distributed in various tissues.

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