Phospho TERF1 (S219) Cell-Based Colorimetric ELISA Kit

  • Catalog No.：KA1536C
  • Applications：ELISA
  • Reactivity：Human;Mouse
    • Gene Name：
    • TERF1
    • Human Gene Id：
    • 7013
    • Human Swiss Prot No：
    • P54274
    • Mouse Swiss Prot No：
    • P70371
    • Storage Stability：
    • 2-8°C/6 months
    • Other Name：
    • Telomeric repeat-binding factor 1 (NIMA-interacting protein 2) (TTAGGG repeat-binding factor 1) (Telomeric protein Pin2/TRF1)
    • Detection Method：
    • Colorimetric
    • Background：
    • domain:The acidic N-terminal domain binds to the ankyrin repeats of TNKS1 and TNKS2. The C-terminal domain binds microtubules.,function:Binds the telomeric double-stranded TTAGGG repeat and negatively regulates telomere length. Involved in the regulation of the mitotic spindle. Component of the shelterin complex (telosome) that is involved in the regulation of telomere length and protection. Shelterin associates with arrays of double-stranded TTAGGG repeats added by telomerase and protects chromosome ends; without its protective activity, telomeres are no longer hidden from the DNA damage surveillance and chromosome ends are inappropriately processed by DNA repair pathways.,induction:Pin2 expression is tightly regulated during the cell cycle; levels are low in G1 and S phase and increase during G2 phase and mitosis.,PTM:ADP-ribosylation by TNKS1 or TNKS2 diminishes its ability to bind to telomeric DNA.,PTM:Phosphorylated preferentially on Ser-219 in an ATM-dependent manner in response to ionizing DNA damage.,similarity:Contains 1 HTH myb-type DNA-binding domain.,subcellular location:Colocalizes with telomeric DNA in interphase and metaphase cells and is located at chromosome ends during metaphase. Associates with the mitotic spindle.,subunit:Homodimer; can contain both isoforms. Found in a complex with POT1; TINF2 and TNKS1. Interacts with ATM, TINF2, TNKS1, TNKS2, PINX1, NEK2 and MAPRE1. Component of the shelterin complex (telosome) composed of TERF1, TERF2, TINF2, TERF2IP ACD and POT1.,tissue specificity:Highly expressed and ubiquitous. Isoform Pin2 predominates.,
    • Function：
    • cell cycle checkpoint, G2/M transition of mitotic cell cycle, M phase of mitotic cell cycle, mitotic cell cycle, M phase,nuclear division, telomere maintenance, progressive alteration of chromatin during cell aging, replicative cell aging,progressive alteration of chromatin during replicative cell aging, age-dependent telomere shortening, DNA metabolic process, DNA replication, regulation of DNA replication, RNA-dependent DNA replication, chromatin organization,protein complex assembly, apoptosis, induction of apoptosis, activation of caspase activity, telomere maintenance via telomerase, cell cycle, mitosis, regulation of mitosis, mitotic cell cycle checkpoint, mitotic cell cycle spindle assembly checkpoint, regulation of mitotic cell cycle, aging, cell aging, negative regulation of DNA replication, cell death, negative regulation of biosynthetic process, negative regulation of macromol
    • Subcellular Location：
    • Nucleus. Cytoplasm, cytoskeleton, spindle. Chromosome, telomere. Colocalizes with telomeric DNA in interphase and prophase cells. Telomeric localization decreases in metaphase, anaphase and telophase. Associates with the mitotic spindle.
    • Expression：
    • Highly expressed and ubiquitous. Isoform Pin2 predominates.

    Attributes

    • Code：
    • KA1536C
    • Size
    • 96 / well
    • Price$：
    • 470
    • Delivery：
    • 2024-08-08
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