Phospho p47 phox (S359) Cell-Based Colorimetric ELISA Kit

  • Catalog No.:KA1520C
  • Applications:ELISA
  • Reactivity:Human
    • Gene Name:
    • NCF1
    • Human Swiss Prot No:
    • P14598
    • Mouse Swiss Prot No:
    • Q09014
    • Storage Stability:
    • 2-8°C/6 months
    • Other Name:
    • Neutrophil cytosol factor 1 (NCF-1) (47 kDa autosomal chronic granulomatous disease protein) (47 kDa neutrophil oxidase factor) (NCF-47K) (Neutrophil NADPH oxidase factor 1) (Nox organizer 2) (Nox-organizing protein 2) (SH3 and PX domain-containing protein 1A) (p47-phox)
    • Detection Method:
    • Colorimetric
    • Background:
    • disease:Defects in NCF1 are the cause of chronic granulomatous disease autosomal recessive cytochrome-b-positive type 1 (CGD1) [MIM:233700]. Chronic granulomatous disease is a genetically heterogeneous disorder characterized by the inability of neutrophils and phagocytes to kill microbes that they have ingested. Patients suffer from life-threatening bacterial/fungal infections.,function:NCF2, NCF1, and a membrane bound cytochrome b558 are required for activation of the latent NADPH oxidase (necessary for superoxide production).,online information:NCF1 deficiency database,similarity:Contains 1 PX (phox homology) domain.,similarity:Contains 2 SH3 domains.,subunit:Interacts with NOXA1.,
    • Function:
    • oxygen and reactive oxygen species metabolic process, superoxide metabolic process, defense response, immune response, cellular defense response, superoxide anion generation, innate immune response, respiratory burst,
    • Subcellular Location:
    • Cytoplasm, cytosol . Membrane ; Peripheral membrane protein ; Cytoplasmic side .
    • Expression:
    • Detected in peripheral blood monocytes and neutrophils (at protein level).