Phospho IL-3Rβ (Y593) Cell-Based Colorimetric ELISA Kit
- Catalog No.:KA1261C
- Applications:ELISA
- Reactivity:Human;Mouse;Rat
- Gene Name:
- CSF2RB
- Human Gene Id:
- 1439
- Human Swiss Prot No:
- P32927
- Mouse Swiss Prot No:
- P26955
- Storage Stability:
- 2-8°C/6 months
- Other Name:
- Cytokine receptor common subunit beta (CDw131) (GM-CSF/IL-3/IL-5 receptor common beta subunit) (CD antigen CD131)
- Detection Method:
- Colorimetric
- Background:
- disease:Defects in CSF2RB are a cause of congenital pulmonary alveolar proteinosis (PAP) [MIM:265120]. PAP is an autosomal recessive fatal respiratory disease.,domain:The box 1 motif is required for JAK interaction and/or activation.,domain:The WSXWS motif appears to be necessary for proper protein folding and thereby efficient intracellular transport and cell-surface receptor binding.,function:High affinity receptor for interleukin-3, interleukin-5 and granulocyte-macrophage colony-stimulating factor.,similarity:Belongs to the type I cytokine receptor family. Type 4 subfamily.,similarity:Contains 2 fibronectin type-III domains.,subunit:Heterodimer of an alpha and a beta subunit. The beta subunit is common to the IL3, IL5 and GM-CSF receptors.,
- Function:
- respiratory gaseous exchange, cytokine-mediated signaling pathway,
- Subcellular Location:
- Membrane; Single-pass type I membrane protein.
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