Phospho CD19 (Y531) Cell-Based Colorimetric ELISA Kit

  • Catalog No.：KA1238C
  • Applications：ELISA
  • Reactivity：Human;Mouse
    • Gene Name：
    • CD19
    • Human Gene Id：
    • 930
    • Human Swiss Prot No：
    • P15391
    • Mouse Swiss Prot No：
    • P25918
    • Storage Stability：
    • 2-8°C/6 months
    • Other Name：
    • B-lymphocyte antigen CD19 (B-lymphocyte surface antigen B4) (Differentiation antigen CD19) (T-cell surface antigen Leu-12) (CD antigen CD19)
    • Detection Method：
    • Colorimetric
    • Background：
    • disease:Defects in CD19 are a cause of hypogammaglobulinemia [MIM:107265].,function:Assembles with the antigen receptor of B lymphocytes in order to decrease the threshold for antigen receptor-dependent stimulation.,online information:CD19 mutation db,PTM:Phosphorylated on serine and threonine upon DNA damage, probably by ATM or ATR. Phosphorylated on tyrosine following B-cell activation.,similarity:Contains 2 Ig-like C2-type (immunoglobulin-like) domains.,subunit:Forms a complex with CD21, CD81 and CD225 in the membrane of mature B cells. Interacts with VAV. Interacts with GRB2 and SOS when phosphorylated on Tyr-348 and/or Tyr-378. Interacts with PLCG2 when phosphorylated on Tyr-409.,
    • Function：
    • activation of immune response, immune response-activating cell surface receptor signaling pathway, positive regulation of immune system process, immune response-activating signal transduction, immune response-regulating signal transduction, immune response-regulating cell surface receptor signaling pathway, defense response, cellular defense response, cell surface receptor linked signal transduction, positive regulation of response to stimulus, positive regulation of immune response, antigen receptor-mediated signaling pathway, B cell receptor signaling pathway,
    • Subcellular Location：
    • Cell membrane ; Single-pass type I membrane protein . Membrane raft ; Single-pass type I membrane protein .
    • Expression：
    • Detected on marginal zone and germinal center B cells in lymph nodes (PubMed:2463100). Detected on blood B cells (at protein level) (PubMed:2463100, PubMed:16672701).

    Attributes

    • Code：
    • KA1238C
    • Size
    • 96 / well
    • Price$：
    • 470
    • Delivery：
    • 2024-12-09
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