• 靶点：
• BEX2

• 基因名称：
• BEX2

• 蛋白名称：
• BEX2

• Human Gene Id：
• 84707

• Human Swiss Prot No：
• Q9BXY8

• Mouse Gene Id：
• 12069

• Mouse Swiss Prot No：
• Q9WTZ8

• Rat Gene Id：
• 363498

• Rat Swiss Prot No：
• Q3MKQ1

• 免疫原：
• Synthesized peptide derived from human BEX2 AA range: 28-78

• 特异性：
• This antibody detects endogenous levels of BEX2 at Human/Mouse/Rat

• 组成：
• Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• 来源：
• Polyclonal, Rabbit,IgG

• 稀释：
• WB 1：500-2000

• 纯化工艺：
• The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

• 浓度：
• 1 mg/ml

• 储存：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• 分子量：
• 14kD

• 背景：
• This gene belongs to the brain expressed X-linked gene family. The encoded protein interacts with the transcription factor LIM domain only 2 in a DNA-binding complex that recognizes the E-box element and promotes transcription. This gene has been found to be a tumor suppressor that is silenced in human glioma. In breast cancer cells, this gene product modulates apoptosis in response to estrogen and tamoxifen, and enhances the anti-proliferative effect of tamoxifen. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2009],

• 功能：
• caution:Was named BEX1 by some authors.,similarity:Belongs to the BEX family.,subunit:Interacts with OMP (By similarity). Interacts with LMO2, possibly leading to regulate the transcriptional activity of a DNA-binding complex containing LMO2.,tissue specificity:Expressed in central nervous system, with high level in pituitary, cerebellum and temporal lobe.,

• 细胞定位：
• Cytoplasm . Nucleus .

• 组织表达：
• Expressed in central nervous system, with high level in pituitary, cerebellum and temporal lobe. Widely expressed in breast cancer cell lines.

Soybean isoflavones protect SH-SY5Y neurons from atrazine-induced toxicity by activating mitophagy through stimulation of the BEX2/BNIP3/NIX pathway. ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY Ecotox Environ Safe. 2021 Dec;227:112886 WB Human 1:1000 Human neuroblastoma SH-SY5Y cell
货号：YT6847

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