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C8AP2 rabbit pAb

货号：YT6423
应用：WB
种属：Human;Mouse

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靶点：
C8AP2

基因名称：
CASP8AP2 FLASH KIAA1315 RIP25

蛋白名称：
C8AP2

Human Gene Id：
9994

Human Swiss Prot No：
Q9UKL3

Mouse Gene Id：
26885

Mouse Swiss Prot No：
Q9WUF3

免疫原：
Synthesized peptide derived from human C8AP2 AA range: 1155-1205

特异性：
This antibody detects endogenous levels of C8AP2 at Human/Mouse

组成：
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

来源：
Polyclonal, Rabbit,IgG

稀释：
WB 1：500-2000

纯化工艺：
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

浓度：
1 mg/ml

储存：
-15°C to -25°C/1 year(Do not lower than -25°C)

分子量：
218kD

背景：
This protein is highly similar to FLASH, a mouse apoptotic protein identified by its interaction with the death-effector domain (DED) of caspase 8. Studies of FLASH protein suggested that this protein may be a component of the death-inducing signaling complex that includes Fas receptor, Fas-binding adapter FADD, and caspase 8, and plays a regulatory role in Fas-mediated apoptosis. Alternative splicing results in multiple transcript variants encoding the same protein.[provided by RefSeq, Nov 2008],

功能：
function:Participates in TNF-alpha-induced blockade of glucocorticoid receptor (GR) transactivation at the nuclear receptor coactivator level, upstream and independently of NF-kappa-B. Suppresses both NCOA2- and NCOA3-induced enhancement of GR transactivation. Involved in TNF-alpha-induced activation of NF-kappa-B via a TRAF2-dependent pathway. Acts as a downstream mediator for CASP8-induced activation of NF-kappa-B. Required for the activation of CASP8 in FAS-mediated apoptosis. Required for histone gene transcription and progression through S phase.,induction:By TNF-alpha, which induces strong nuclear localization.,PTM:Phosphorylated upon DNA damage, probably by ATM or ATR.,sequence caution:Contaminating sequence. Potential poly-A sequence starting in position 364.,subcellular location:Localizes to discrete nuclear foci.,subunit:Self-associates. Component of the death-inducing signalin

细胞定位：
Cytoplasm. Nucleus. Nucleus, PML body. Mitochondrion. Exported from the nucleus to the mitochondria upon FAS activation.

Downregulating CREBBP inhibits proliferation and cell cycle progression and induces daunorubicin resistance in leukemia cells. Molecular Medicine Reports Mol Med Rep. 2020 Oct;22(4):2905-2915 WB Human 1:500 Jurkat cell， Reh cell
货号：YT6423