• 靶点：
• SC6A4

• 简介：
• >>Synaptic vesicle cycle;>>Serotonergic synapse

• 基因名称：
• SLC6A4 HTT SERT

• 蛋白名称：
• SC6A4

• Human Gene Id：
• 6532

• Human Swiss Prot No：
• P31645

• 免疫原：
• Synthesized peptide derived from human SC6A4

• 特异性：
• This antibody detects endogenous levels of human SC6A4

• 组成：
• Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• 来源：
• Polyclonal, Rabbit,IgG

• 稀释：
• WB 1:500 - 1:2000. IHC 1:100 - 1:300. IF 1:200 - 1:1000. ELISA: 1:40000. Not yet tested in other applications.

• 纯化工艺：
• The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

• 浓度：
• 1 mg/ml

• 储存：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• 其他名称：
• Sodium-dependent serotonin transporter (5HT transporter;5HTT;Solute carrier family 6 member 4)

• 实测条带：
• 69kD

• 背景：
• This gene encodes an integral membrane protein that transports the neurotransmitter serotonin from synaptic spaces into presynaptic neurons. The encoded protein terminates the action of serotonin and recycles it in a sodium-dependent manner. This protein is a target of psychomotor stimulants, such as amphetamines and cocaine, and is a member of the sodium:neurotransmitter symporter family. A repeat length polymorphism in the promoter of this gene has been shown to affect the rate of serotonin uptake and may play a role in sudden infant death syndrome, aggressive behavior in Alzheimer disease patients, and depression-susceptibility in people experiencing emotional trauma. [provided by RefSeq, Jul 2008],

• 功能：
• function:Terminates the action of serotonin by its high affinity sodium-dependent reuptake into presynaptic terminals.,miscellaneous:This protein is the target of psychomotor stimulants such as amphetamines or cocaine.,online information:Serotonin transporter entry,online information:The Singapore human mutation and polymorphism database,polymorphism:A polymorphism in the promoter region (5-HTT gene-linked polymorphic region, 5-HTTLPR) is located approximately 1 kb upstream of the transcription initiation site and is composed of 16 repeat elements. The polymorphism consists of a 44-bp insertion or deletion involving repeat elements 6 to 8. The short allele is associated with lower transcriptional efficiency of the promoter compared with the long allele. Over half of the Caucasian population has a short allele. Individuals with one or two copies of the short allele exhibit more depressive

• 细胞定位：
• Cell membrane ; Multi-pass membrane protein . Endomembrane system ; Multi-pass membrane protein . Endosome membrane ; Multi-pass membrane protein . Cell junction, synapse . Cell junction, focal adhesion . Could be part of recycling endosomes (PubMed:16870614). Density of transporter molecules on the plasma membrane is itself regulated by STX1A (By similarity). Density of transporter molecules on the plasma membrane is also regulated by serotonin (PubMed:17506858). Density of transporter molecules seems to be modulated by ITGAV:ITGB3 (By similarity). .

• 组织表达：
• Expressed in platelets (at protein level).

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