• 靶点：
• Claudin 11

• 简介：
• >>Cell adhesion molecules;>>Tight junction;>>Leukocyte transendothelial migration;>>Pathogenic Escherichia coli infection;>>Hepatitis C

• 基因名称：
• CLDN11 OSP OTM

• 蛋白名称：
• Claudin-11 (Oligodendrocyte-specific protein)

• Human Gene Id：
• 5010

• Human Swiss Prot No：
• O75508

• Mouse Gene Id：
• 18417

• Mouse Swiss Prot No：
• Q60771

• Rat Swiss Prot No：
• Q99P82

• 免疫原：
• Synthesized peptide derived from human Claudin 11

• 特异性：
• This antibody detects endogenous levels of Claudin 11 Antibody

• 组成：
• Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• 来源：
• Polyclonal, Rabbit,IgG

• 稀释：
• WB 1:500-2000, ELISA 1:10000-20000

• 纯化工艺：
• The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

• 浓度：
• 1 mg/ml

• 储存：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• 其他名称：
• Claudin-11 (Oligodendrocyte-specific protein)

• 实测条带：
• 20kD

• 背景：
• This gene encodes a member of the claudin family. Claudins are integral membrane proteins and components of tight junction strands. Tight junction strands serve as a physical barrier to prevent solutes and water from passing freely through the paracellular space between epithelial or endothelial cell sheets, and also play critical roles in maintaining cell polarity and signal transductions. The protein encoded by this gene is a major component of central nervous system (CNS) myelin and plays an important role in regulating proliferation and migration of oligodendrocytes. Mouse studies showed that the gene deficiency results in deafness and loss of the Sertoli cell epithelial phenotype in the testis. This protein is a tight junction protein at the human blood-testis barrier (BTB), and the BTB disruption is related to a dysfunction of this gene. Alternatively spliced transcript variants encoding different iso

• 功能：
• function:Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.,similarity:Belongs to the claudin family.,subunit:Interacts with tetraspanin-3/TSPAN3.,

• 细胞定位：
• Cell junction, tight junction. Cell membrane ; Multi-pass membrane protein .

• 组织表达：
• Lung,Spinal cord,

Nickel induces blood-testis barrier damage through ROS-mediated p38 MAPK pathways in mice. Redox Biology Hongrui Guo WB Mouse testis tissue TM4 cell
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