- 靶点:
- ST2
- 简介:
- >>Cytokine-cytokine receptor interaction
- 基因名称:
- IL1RL1 DER4 ST2 T1
- 蛋白名称:
- Interleukin-1 receptor-like 1 (Protein ST2)
- Human Gene Id:
- 9173
- Human Swiss Prot No:
- Q01638
- Mouse Gene Id:
- 17082
- Mouse Swiss Prot No:
- P14719
- 免疫原:
- Synthetic peptide from human protein at AA range: 251-300
- 特异性:
- The antibody detects endogenous ST2
- 组成:
- Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
- 来源:
- Polyclonal, Rabbit,IgG
- 稀释:
- WB 1:500 - 1:2000. IHC 1:100 - 1:300. IF 1:200 - 1:1000. ELISA: 1:20000. Not yet tested in other applications.
- 纯化工艺:
- The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
- 浓度:
- 1 mg/ml
- 储存:
- -15°C to -25°C/1 year(Do not lower than -25°C)
- 其他名称:
- Interleukin-1 receptor-like 1 (Protein ST2)
- 分子量:
- 63kD
- 背景:
- The protein encoded by this gene is a member of the interleukin 1 receptor family. Studies of the similar gene in mouse suggested that this receptor can be induced by proinflammatory stimuli, and may be involved in the function of helper T cells. This gene, interleukin 1 receptor, type I (IL1R1), interleukin 1 receptor, type II (IL1R2) and interleukin 1 receptor-like 2 (IL1RL2) form a cytokine receptor gene cluster in a region mapped to chromosome 2q12. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Jul 2008],
- 功能:
- function:Receptor for interleukin-33 (IL-33), its stimulation recruits MYD88, IRAK1, IRAK4, and TRAF6, followed by phosphorylation of MAPK3/ERK1 and/or MAPK1/ERK2, MAPK14, and MAPK8. Possibly involved in helper T-cell function.,similarity:Belongs to the interleukin-1 receptor family.,similarity:Contains 1 TIR domain.,similarity:Contains 3 Ig-like C2-type (immunoglobulin-like) domains.,subunit:Interacts with MYD88, IRAK1, IRAK4, and TRAF6.,tissue specificity:Highly expressed in kidney, lung, placenta, stomach, skeletal muscle, colon and small intestine. Expression of isoform A is prevalent in the lung, testis, placenta, stomach and colon. However, isoform B is more abundant in the brain, kidney and the liver. Isoform C is not detected in brain, heart, liver, kidney and skeletal muscle.,
- 细胞定位:
- [Isoform C]: Cell membrane.; [Isoform B]: Secreted.; Cell membrane ; Single-pass type I membrane protein .
- 组织表达:
- Highly expressed in kidney, lung, placenta, stomach, skeletal muscle, colon and small intestine. Isoform A is prevalently expressed in the lung, testis, placenta, stomach and colon. Isoform B is more abundant in the brain, kidney and the liver. Isoform C is not detected in brain, heart, liver, kidney and skeletal muscle. Expressed on T-cells in fibrotic liver; at protein level. Overexpressed in fibrotic and cirrhotic liver.
Relevance of serum interleukin-33 and ST2 levels and the natural course of chronic hepatitis B virus infection. BMC INFECTIOUS DISEASES 2016 May 16 ELISA Human Sera
货号:YT5992
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- Antibody-FAQs
- 产品图片
- Zhang, Zhihui, et al. "Serum levels of soluble ST2 and IL-10 are associated with disease severity in patients with IgA nephropathy." Journal of immunology research 2016 (2016).
- Immunohistochemical analysis of paraffin-embedded human-liver, antibody was diluted at 1:200