• 靶点：
• ST2

• 简介：
• >>Cytokine-cytokine receptor interaction

• 基因名称：
• IL1RL1 DER4 ST2 T1

• 蛋白名称：
• Interleukin-1 receptor-like 1 (Protein ST2)

• Human Gene Id：
• 9173

• Human Swiss Prot No：
• Q01638

• Mouse Gene Id：
• 17082

• Mouse Swiss Prot No：
• P14719

• 免疫原：
• Synthetic peptide from human protein at AA range: 251-300

• 特异性：
• The antibody detects endogenous ST2

• 组成：
• Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• 来源：
• Polyclonal, Rabbit,IgG

• 稀释：
• WB 1:500 - 1:2000. IHC 1:100 - 1:300. IF 1:200 - 1:1000. ELISA: 1:20000. Not yet tested in other applications.

• 纯化工艺：
• The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

• 浓度：
• 1 mg/ml

• 储存：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• 其他名称：
• Interleukin-1 receptor-like 1 (Protein ST2)

• 分子量：
• 63kD

• 背景：
• The protein encoded by this gene is a member of the interleukin 1 receptor family. Studies of the similar gene in mouse suggested that this receptor can be induced by proinflammatory stimuli, and may be involved in the function of helper T cells. This gene, interleukin 1 receptor, type I (IL1R1), interleukin 1 receptor, type II (IL1R2) and interleukin 1 receptor-like 2 (IL1RL2) form a cytokine receptor gene cluster in a region mapped to chromosome 2q12. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Jul 2008],

• 功能：
• function:Receptor for interleukin-33 (IL-33), its stimulation recruits MYD88, IRAK1, IRAK4, and TRAF6, followed by phosphorylation of MAPK3/ERK1 and/or MAPK1/ERK2, MAPK14, and MAPK8. Possibly involved in helper T-cell function.,similarity:Belongs to the interleukin-1 receptor family.,similarity:Contains 1 TIR domain.,similarity:Contains 3 Ig-like C2-type (immunoglobulin-like) domains.,subunit:Interacts with MYD88, IRAK1, IRAK4, and TRAF6.,tissue specificity:Highly expressed in kidney, lung, placenta, stomach, skeletal muscle, colon and small intestine. Expression of isoform A is prevalent in the lung, testis, placenta, stomach and colon. However, isoform B is more abundant in the brain, kidney and the liver. Isoform C is not detected in brain, heart, liver, kidney and skeletal muscle.,

• 细胞定位：
• [Isoform C]: Cell membrane.; [Isoform B]: Secreted.; Cell membrane ; Single-pass type I membrane protein .

• 组织表达：
• Highly expressed in kidney, lung, placenta, stomach, skeletal muscle, colon and small intestine. Isoform A is prevalently expressed in the lung, testis, placenta, stomach and colon. Isoform B is more abundant in the brain, kidney and the liver. Isoform C is not detected in brain, heart, liver, kidney and skeletal muscle. Expressed on T-cells in fibrotic liver; at protein level. Overexpressed in fibrotic and cirrhotic liver.

Relevance of serum interleukin-33 and ST2 levels and the natural course of chronic hepatitis B virus infection. BMC INFECTIOUS DISEASES 2016 May 16 ELISA Human Sera
货号：YT5992

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