- 基因名称:
- IL1RL1
- 蛋白名称:
- Interleukin-1 receptor-like 1
- Human Gene Id:
- 9173
- Human Swiss Prot No:
- Q01638
- Mouse Swiss Prot No:
- P14719
- 特异性:
- Sample Type for Cell Culture Supernates, Cell lysates, Tissue Lysates, Serum, EDTA Plasma, Heparin Plasma
- 储存:
- 2-8°C/6 months
- 其他名称:
- IL1RL1;DER4;ST2;T1;Interleukin-1 receptor-like 1;Protein ST2
- 检测方法:
- Colorimetric
- 背景:
- function:Receptor for interleukin-33 (IL-33), its stimulation recruits MYD88, IRAK1, IRAK4, and TRAF6, followed by phosphorylation of MAPK3/ERK1 and/or MAPK1/ERK2, MAPK14, and MAPK8. Possibly involved in helper T-cell function.,similarity:Belongs to the interleukin-1 receptor family.,similarity:Contains 1 TIR domain.,similarity:Contains 3 Ig-like C2-type (immunoglobulin-like) domains.,subunit:Interacts with MYD88, IRAK1, IRAK4, and TRAF6.,tissue specificity:Highly expressed in kidney, lung, placenta, stomach, skeletal muscle, colon and small intestine. Expression of isoform A is prevalent in the lung, testis, placenta, stomach and colon. However, isoform B is more abundant in the brain, kidney and the liver. Isoform C is not detected in brain, heart, liver, kidney and skeletal muscle.,
- 功能:
- defense response, immune response, negative regulation of signal transduction, regulation of protein kinase cascade,negative regulation of cell communication, negative regulation of protein kinase cascade, regulation of I-kappaB kinase/NF-kappaB cascade, negative regulation of I-kappaB kinase/NF-kappaB cascade, innate immune response,
- 细胞定位:
- [Isoform C]: Cell membrane.; [Isoform B]: Secreted.; Cell membrane ; Single-pass type I membrane protein .
- 组织表达:
- Highly expressed in kidney, lung, placenta, stomach, skeletal muscle, colon and small intestine. Isoform A is prevalently expressed in the lung, testis, placenta, stomach and colon. Isoform B is more abundant in the brain, kidney and the liver. Isoform C is not detected in brain, heart, liver, kidney and skeletal muscle. Expressed on T-cells in fibrotic liver; at protein level. Overexpressed in fibrotic and cirrhotic liver.
Serum Levels of Soluble ST2 and IL-10 Are Associated with Disease Severity in Patients with IgA Nephropathy. Journal of Immunology Research J Immunol Res. 2016;2016:6540937 ELISA Human sera
货号:KE1248
Relevance of serum interleukin-33 and ST2 levels and the natural course of chronic hepatitis B virus infection. BMC INFECTIOUS DISEASES 2016 May 16 ELISA Human Sera
货号:KE1248
Serum ST2 in inflammatory bowel disease: a potential biomarker for disease activity. JOURNAL OF INVESTIGATIVE MEDICINE J Invest Med. 2016 Jun;64(5):1016-1024 ELISA Human Serum
货号:KE1248
Overexpression of serum sST2 is associated with poor prognosis in acute-on-chronic hepatitis B liver failure. Clinics and Research in Hepatology and Gastroenterology 2014 Nov 11 ELISA Human serum
货号:KE1248
Increased soluble ST2 and IL‑4 serum levels are associated with disease severity in patients with membranous nephropathy. Molecular Medicine Reports 2017 Nov 22 ELISA Human Serum
货号:KE1248
Relevance of serum interleukin-33 and ST2 levels and the natural course of chronic hepatitis B virus infection. BMC INFECTIOUS DISEASES 2016 May 16 ELISA Human Sera
货号:KE1248
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- 产品图片
- Huan, Shu-Ling, et al. "Relevance of serum interleukin-33 and ST2 levels and the natural course of chronic hepatitis B virus infection." BMC infectious diseases 16.1 (2016): 200.
- The Human ST2 ELISA Kit allows for the detection and quantification of endogenous levels of natural and/or recombinant Human ST2 proteins within the range of 32-2000 pg/ml.