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LT-β Polyclonal Antibody

货号：YT5971
应用：WB;IHC;IF;ELISA
种属：Human;Mouse

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靶点：
LT-β

简介：
>>Cytokine-cytokine receptor interaction;>>NF-kappa B signaling pathway;>>Rheumatoid arthritis

基因名称：
LTB TNFC TNFSF3

蛋白名称：
Lymphotoxin-beta (LT-beta) (Tumor necrosis factor C) (TNF-C) (Tumor necrosis factor ligand superfamily member 3)

Human Gene Id：
4050

Human Swiss Prot No：
Q06643

Mouse Gene Id：
16994

Mouse Swiss Prot No：
P41155

免疫原：
Synthetic peptide from human protein at AA range: 41-90

特异性：
The antibody detects endogenous LT-β

组成：
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

来源：
Polyclonal, Rabbit,IgG

稀释：
IHC 1:50-200, ELISA 1:10000-20000,WB 1:500-2000. IF 1:50-200

纯化工艺：
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

浓度：
1 mg/ml

储存：
-15°C to -25°C/1 year(Do not lower than -25°C)

其他名称：
Lymphotoxin-beta (LT-beta;Tumor necrosis factor C;TNF-C;Tumor necrosis factor ligand superfamily member 3)

分子量：
25kD

背景：
Lymphotoxin beta is a type II membrane protein of the TNF family. It anchors lymphotoxin-alpha to the cell surface through heterotrimer formation. The predominant form on the lymphocyte surface is the lymphotoxin-alpha 1/beta 2 complex (e.g. 1 molecule alpha/2 molecules beta) and this complex is the primary ligand for the lymphotoxin-beta receptor. The minor complex is lymphotoxin-alpha 2/beta 1. LTB is an inducer of the inflammatory response system and involved in normal development of lymphoid tissue. Lymphotoxin-beta isoform b is unable to complex with lymphotoxin-alpha suggesting a function for lymphotoxin-beta which is independent of lympyhotoxin-alpha. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008],

功能：
function:Cytokine that binds to LTBR/TNFRSF3. May play a specific role in immune response regulation. Provides the membrane anchor for the attachment of the heterotrimeric complex to the cell surface. Isoform 2 is probably non-functional.,similarity:Belongs to the tumor necrosis factor family.,subunit:Heterotrimer of either two LTB and one LTA subunits or (less prevalent) one LTB and two LTA subunits.,tissue specificity:Spleen and thymus.,

细胞定位：
Membrane ; Single-pass type II membrane protein .

组织表达：
Spleen and thymus.

Sacubitril/Valsartan Alleviates Experimental Autoimmune Myocarditis by Inhibiting Th17 Cell Differentiation Independently of the NLRP3 Inflammasome Pathway. Frontiers in Pharmacology Front Pharmacol. 2021; 12: 727838 WB Mouse 1:1000 Myocardial tissues
货号：YT5971