• 靶点：
• CD168

• 简介：
• >>ECM-receptor interaction

• 基因名称：
• HMMR IHABP RHAMM

• 蛋白名称：
• Hyaluronan mediated motility receptor (Intracellular hyaluronic acid-binding protein) (Receptor for hyaluronan-mediated motility) (CD antigen CD168)

• Human Gene Id：
• 3161

• Human Swiss Prot No：
• O75330

• Mouse Gene Id：
• 15366

• Mouse Swiss Prot No：
• Q00547

• 免疫原：
• Synthetic peptide from human protein at AA range: 280-340

• 特异性：
• The antibody detects endogenous CD168

• 组成：
• Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• 来源：
• Polyclonal, Rabbit,IgG

• 稀释：
• WB 1:500-2000,IHC 1:500-200, ELISA 1:10000-20000. IF 1:50-200

• 纯化工艺：
• The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

• 浓度：
• 1 mg/ml

• 储存：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• 其他名称：
• Hyaluronan mediated motility receptor (Intracellular hyaluronic acid-binding protein;Receptor for hyaluronan-mediated motility;CD antigen CD168)

• 实测条带：
• 84kD

• 背景：
• The protein encoded by this gene is involved in cell motility. It is expressed in breast tissue and together with other proteins, it forms a complex with BRCA1 and BRCA2, thus is potentially associated with higher risk of breast cancer. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene. [provided by RefSeq, Dec 2008],

• 功能：
• function:Involved in cell motility. When hyaluronan binds to HMMR, the phosphorylation of a number of proteins, including the focal adhesion kinase occurs. May also be involved in cellular transformation and metastasis formation, and in regulating extracellular-regulated kinase (ERK) activity.,subunit:Subunit of the HARC complex.,tissue specificity:Expressed in breast cancer cell lines and in normal breast tissue.,

• 细胞定位：
• Cell surface . Cytoplasm . Cytoplasm, cytoskeleton, spindle .

• 组织表达：
• Expressed in testis (PubMed:22965910). Expressed in the breast (PubMed:8890751).

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