• 靶点：
• CD19

• 简介：
• >>PI3K-Akt signaling pathway;>>Hematopoietic cell lineage;>>B cell receptor signaling pathway;>>Epstein-Barr virus infection;>>Primary immunodeficiency

• 基因名称：
• CD19

• 蛋白名称：
• B-lymphocyte antigen CD19

• Human Gene Id：
• 930

• Human Swiss Prot No：
• P15391

• Mouse Swiss Prot No：
• P25918

• 免疫原：
• Synthesized peptide derived from B-lymphocyte antigen CD19 at AA range: 191-240

• 特异性：
• CD19 Polyclonal Antibody detects endogenous levels of CD19 protein.

• 组成：
• Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• 来源：
• Polyclonal, Rabbit,IgG

• 稀释：
• WB 1:500-2000;Flow Cyt 1:50-200;IHC 1:100-500;IF(paraffin section);ELISA 1:5000-20000

• 纯化工艺：
• The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

• 浓度：
• 1 mg/ml

• 储存：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• 其他名称：
• CD19;B-lymphocyte antigen CD19;B-lymphocyte surface antigen B4;Differentiation antigen CD19;T-cell surface antigen Leu-12;CD19

• 实测条带：
• 61kD

• 背景：
• Lymphocytes proliferate and differentiate in response to various concentrations of different antigens. The ability of the B cell to respond in a specific, yet sensitive manner to the various antigens is achieved with the use of low-affinity antigen receptors. This gene encodes a cell surface molecule which assembles with the antigen receptor of B lymphocytes in order to decrease the threshold for antigen receptor-dependent stimulation. [provided by RefSeq, Jul 2008],

• 功能：
• disease:Defects in CD19 are a cause of hypogammaglobulinemia [MIM:107265].,function:Assembles with the antigen receptor of B lymphocytes in order to decrease the threshold for antigen receptor-dependent stimulation.,online information:CD19 mutation db,PTM:Phosphorylated on serine and threonine upon DNA damage, probably by ATM or ATR. Phosphorylated on tyrosine following B-cell activation.,similarity:Contains 2 Ig-like C2-type (immunoglobulin-like) domains.,subunit:Forms a complex with CD21, CD81 and CD225 in the membrane of mature B cells. Interacts with VAV. Interacts with GRB2 and SOS when phosphorylated on Tyr-348 and/or Tyr-378. Interacts with PLCG2 when phosphorylated on Tyr-409.,

• 细胞定位：
• Cell membrane ; Single-pass type I membrane protein . Membrane raft ; Single-pass type I membrane protein .

• 组织表达：
• Detected on marginal zone and germinal center B cells in lymph nodes (PubMed:2463100). Detected on blood B cells (at protein level) (PubMed:2463100, PubMed:16672701).

Longitudinal Immune Profiling Highlights CD4+ T Cell Exhaustion Correlated with Liver Fibrosis in Schistosoma japonicum Infection JOURNAL OF IMMUNOLOGY Zhiqiang Qin IF,IHC Mouse livers
货号：YT5580

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