• 靶点：
• CD71/TfR

• 简介：
• >>HIF-1 signaling pathway;>>Endocytosis;>>Phagosome;>>Ferroptosis;>>Hematopoietic cell lineage

• 基因名称：
• TFRC

• 蛋白名称：
• Transferrin receptor protein 1

• Human Gene Id：
• 7037

• Human Swiss Prot No：
• P02786

• Mouse Swiss Prot No：
• Q62351

• 免疫原：
• The antiserum was produced against synthesized peptide derived from the N-terminal region of human TFRC. AA range:101-150

• 特异性：
• CD71 Polyclonal Antibody detects endogenous levels of CD71 protein.

• 组成：
• Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• 来源：
• Polyclonal, Rabbit,IgG

• 稀释：
• WB 1:500 - 1:2000. IHC: 1:100-1:300. ELISA: 1:20000.. IF 1:50-200

• 纯化工艺：
• The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

• 浓度：
• 1 mg/ml

• 储存：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• 其他名称：
• TFRC;Transferrin receptor protein 1;TR;TfR;TfR1;Trfr;T9;p90;CD71

• 实测条带：
• 85kD

• 背景：
• This gene encodes a cell surface receptor necessary for cellular iron uptake by the process of receptor-mediated endocytosis. This receptor is required for erythropoiesis and neurologic development. Multiple alternatively spliced variants have been identified. [provided by RefSeq, Sep 2015],

• 功能：
• function:Cellular uptake of iron occurs via receptor-mediated endocytosis of ligand-occupied transferrin receptor into specialized endosomes. Endosomal acidification leads to iron release. The apotransferrin-receptor complex is then recycled to the cell surface with a return to neutral pH and the concomitant loss of affinity of apotransferrin for its receptor. Transferrin receptor is necessary for development of erythrocytes and the nervous system (By similarity). A second ligand, the heditary hemochromatosis protein HFE, competes for binding with transferrin for an overlapping C-terminal binding site.,induction:Regulated by cellular iron levels through binding of the iron regulatory proteins, IRP1 and IRP2, to iron-responsive elements in the 3'-UTR. Up-regulated upon mitogenic stimulation.,miscellaneous:Canine and feline parvoviruses bind human and feline transferrin receptors and use t

• 细胞定位：
• Cell membrane ; Single-pass type II membrane protein . Melanosome . Identified by mass spectrometry in melanosome fractions from stage I to stage IV. .; [Transferrin receptor protein 1, serum form]: Secreted .

• 组织表达：
• Brain,Epithelium,Erythroleukemia,Eye,Human endometrium carcinoma cell line,Liver,Pl

Effect of atrazine on accumulation of iron via the iron transport proteins in the midbrain of SD rats. SCIENCE OF THE TOTAL ENVIRONMENT Sci Total Environ. 2021 Aug;780:146666 WB Rat 1:300 Midbrain
货号：YT5374

Identification of iron metabolism-related genes as prognostic indicators for papillary thyroid carcinoma: a retrospective study. Minghua Ge WB Human TPC-1 cell
货号：YT5374

Deferoxamine attenuates visual impairment in retinal ischemia‒reperfusion via inhibiting ferroptosis Scientific Reports Wang Xiaoxuan WB Rat 1:500 retina tissue
货号：YT5374

Sunitinib induces cardiotoxicity through modulating oxidative stress and Nrf2-dependent ferroptosis in vitro and in vivo CHEMICO-BIOLOGICAL INTERACTIONS Dongjie Li WB Mouse,Rat heart tissue H9c2 cell
货号：YT5374

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