• 靶点：
• β-1,4-GalNAc-T

• 简介：
• >>Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate;>>Metabolic pathways

• 基因名称：
• CSGALNACT1

• 蛋白名称：
• Chondroitin sulfate N-acetylgalactosaminyltransferase 1

• Human Gene Id：
• 55790

• Human Swiss Prot No：
• Q8TDX6

• Mouse Gene Id：
• 234356

• Mouse Swiss Prot No：
• Q8BJQ9

• 免疫原：
• The antiserum was produced against synthesized peptide derived from human CSGALNACT1. AA range:201-250

• 特异性：
• β-1,4-GalNAc-T Polyclonal Antibody detects endogenous levels of β-1,4-GalNAc-T protein.

• 组成：
• Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• 来源：
• Polyclonal, Rabbit,IgG

• 稀释：
• WB 1:500 - 1:2000. IHC 1:100 - 1:300. ELISA: 1:40000.. IF 1:50-200

• 纯化工艺：
• The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

• 浓度：
• 1 mg/ml

• 储存：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• 其他名称：
• CSGALNACT1;CHGN;GALNACT1;Chondroitin sulfate N-acetylgalactosaminyltransferase 1;CsGalNAcT-1;Chondroitin beta-1;4-N-acetylgalactosaminyltransferase 1;Beta4GalNAcT-1

• 实测条带：
• 60kD

• 背景：
• catalytic activity:UDP-N-acetyl-D-galactosamine + beta-D-glucuronyl-(1->3)-D-galactosyl-proteoglycan = UDP + N-acetyl-D-galactosaminyl-(1->4)-beta-D-glucuronyl-(1->3)-beta-D-galactosylproteoglycan.,function:Transfers 1,4-N-acetylgalactosamine (GalNAc) from UDP-GalNAc to the non-reducing end of glucuronic acid (GlcUA). Required for addition of the first GalNAc to the core tetrasaccharide linker and for elongation of chondroitin chains. Important role in chondroitin chain biosynthesis in cartilage.,online information:Chondroitin beta-1,4-N-acetylgalactosaminyltransferase 1,online information:GlycoGene database,PTM:N-glycosylated.,similarity:Belongs to the chondroitin N-acetylgalactosaminyltransferase family.,tissue specificity:Ubiquitous, with the highest levels in placenta, thyroid, bladder, prostate and adrenal gland. Detected at low levels in the other tissues examined.,

• 功能：
• catalytic activity:UDP-N-acetyl-D-galactosamine + beta-D-glucuronyl-(1->3)-D-galactosyl-proteoglycan = UDP + N-acetyl-D-galactosaminyl-(1->4)-beta-D-glucuronyl-(1->3)-beta-D-galactosylproteoglycan.,function:Transfers 1,4-N-acetylgalactosamine (GalNAc) from UDP-GalNAc to the non-reducing end of glucuronic acid (GlcUA). Required for addition of the first GalNAc to the core tetrasaccharide linker and for elongation of chondroitin chains. Important role in chondroitin chain biosynthesis in cartilage.,online information:Chondroitin beta-1,4-N-acetylgalactosaminyltransferase 1,online information:GlycoGene database,PTM:N-glycosylated.,similarity:Belongs to the chondroitin N-acetylgalactosaminyltransferase family.,tissue specificity:Ubiquitous, with the highest levels in placenta, thyroid, bladder, prostate and adrenal gland. Detected at low levels in the other tissues examined.,

• 细胞定位：
• Golgi apparatus, Golgi stack membrane ; Single-pass type II membrane protein .

• 组织表达：
• Ubiquitous, with the highest levels in placenta, thyroid, bladder, prostate and adrenal gland. Detected at low levels in the other tissues examined.

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