• 靶点：
• WAVE3

• 简介：
• >>Adherens junction;>>Fc gamma R-mediated phagocytosis;>>Pathogenic Escherichia coli infection;>>Salmonella infection;>>Choline metabolism in cancer

• 基因名称：
• WASF3

• 蛋白名称：
• Wiskott-Aldrich syndrome protein family member 3

• Human Gene Id：
• 10810

• Human Swiss Prot No：
• Q9UPY6

• Mouse Gene Id：
• 245880

• Mouse Swiss Prot No：
• Q8VHI6

• 免疫原：
• The antiserum was produced against synthesized peptide derived from human WASF3. AA range:151-200

• 特异性：
• WAVE3 Polyclonal Antibody detects endogenous levels of WAVE3 protein.

• 组成：
• Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• 来源：
• Polyclonal, Rabbit,IgG

• 稀释：
• WB 1:500 - 1:2000. IHC 1:100 - 1:300. ELISA: 1:10000.. IF 1:50-200

• 纯化工艺：
• The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

• 浓度：
• 1 mg/ml

• 储存：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• 其他名称：
• WASF3;KIAA0900;SCAR3;WAVE3;Wiskott-Aldrich syndrome protein family member 3;WASP family protein member 3;Protein WAVE-3;Verprolin homology domain-containing protein 3

• 实测条带：
• 55kD

• 背景：
• This gene encodes a member of the Wiskott-Aldrich syndrome protein family. The gene product is a protein that forms a multiprotein complex that links receptor kinases and actin. Binding to actin occurs through a C-terminal verprolin homology domain in all family members. The multiprotein complex serves to tranduce signals that involve changes in cell shape, motility or function. A pseudogene of this gene have been defined on chromosome 6. Alternative splicing results in multiple transcript variants [provided by RefSeq, May 2014],

• 功能：
• domain:Binds the Arp2/3 complex through the C-terminal region and actin through verprolin homology (VPH) domain.,function:Downstream effector molecules involved in the transmission of signals from tyrosine kinase receptors and small GTPases to the actin cytoskeleton.,similarity:Belongs to the SCAR/WAVE family.,similarity:Contains 1 WH2 domain.,subunit:Binds actin and the Arp2/3 complex.,tissue specificity:Expressed in ovary and brain.,

• 细胞定位：
• Cytoplasm, cytoskeleton.

• 组织表达：
• Expressed in ovary and brain.

Cucurbitacin B inhibits the migration and invasion of breast cancer cells by altering the biomechanical properties of cells. PHYTOTHERAPY RESEARCH Phytother Res. 2019 Mar;33(3):618-630 WB Human 1:1000 MDA-MB-231 cell， SKBR-3 cell
货号：YT4899

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