• 靶点：
• UBA2

• 简介：
• >>Ubiquitin mediated proteolysis

• 基因名称：
• UBA2

• 蛋白名称：
• SUMO-activating enzyme subunit 2

• Human Gene Id：
• 10054

• Human Swiss Prot No：
• Q9UBT2

• Mouse Swiss Prot No：
• Q9Z1F9

• 免疫原：
• The antiserum was produced against synthesized peptide derived from human Uba2. AA range:591-640

• 特异性：
• UBA2 Polyclonal Antibody detects endogenous levels of UBA2 protein.

• 组成：
• Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• 来源：
• Polyclonal, Rabbit,IgG

• 稀释：
• WB 1:500 - 1:2000. IHC 1:100 - 1:300. IF 1:200 - 1:1000. ELISA: 1:10000. Not yet tested in other applications.

• 纯化工艺：
• The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

• 浓度：
• 1 mg/ml

• 储存：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• 其他名称：
• UBA2;SAE2;UBLE1B;HRIHFB2115;SUMO-activating enzyme subunit 2;Anthracycline-associated resistance ARX;Ubiquitin-like 1-activating enzyme E1B

• 实测条带：
• 71kD

• 背景：
• Posttranslational modification of proteins by the addition of the small protein SUMO (see SUMO1; MIM 601912), or sumoylation, regulates protein structure and intracellular localization. SAE1 (MIM 613294) and UBA2 form a heterodimer that functions as a SUMO-activating enzyme for the sumoylation of proteins (Okuma et al., 1999 [PubMed 9920803]).[supplied by OMIM, Mar 2010],

• 功能：
• function:The dimeric enzyme acts as a E1 ligase for SUMO1, SUMO2, SUMO3, and probably SUMO4. It mediates ATP-dependent activation of SUMO proteins and formation of a thioester with a conserved cysteine residue on SAE2.,pathway:Protein modification; protein sumoylation.,similarity:Belongs to the ubiquitin-activating E1 family.,subunit:Heterodimer of SAE1 and SAE2. The complex binds SUMO proteins via SAE2.,

• 细胞定位：
• Cytoplasm. Nucleus. Shuttles between the cytoplasm and the nucleus, sumoylation is required either for nuclear translocation or nuclear retention.

• 组织表达：
• Brain,Cervix carcinoma,Fetal brain,Placenta,Skin,Testis,

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