• 基因名称：
• UBA2

• Human Gene Id：
• 10054

• Human Swiss Prot No：
• Q9UBT2

• Mouse Swiss Prot No：
• Q9Z1F9

• 储存：
• 2-8°C/6 months

• 其他名称：
• SUMO-activating enzyme subunit 2 (EC 6.3.2.-) (Anthracycline-associated resistance ARX) (Ubiquitin-like 1-activating enzyme E1B)

• 检测方法：
• Colorimetric

• 背景：
• function:The dimeric enzyme acts as a E1 ligase for SUMO1, SUMO2, SUMO3, and probably SUMO4. It mediates ATP-dependent activation of SUMO proteins and formation of a thioester with a conserved cysteine residue on SAE2.,pathway:Protein modification; protein sumoylation.,similarity:Belongs to the ubiquitin-activating E1 family.,subunit:Heterodimer of SAE1 and SAE2. The complex binds SUMO proteins via SAE2.,

• 功能：
• proteolysis, macromolecule catabolic process, modification-dependent protein catabolic process, protein catabolic process, modification-dependent macromolecule catabolic process, cellular protein catabolic process, cellular macromolecule catabolic process, proteolysis involved in cellular protein catabolic process,

• 细胞定位：
• Cytoplasm. Nucleus. Shuttles between the cytoplasm and the nucleus, sumoylation is required either for nuclear translocation or nuclear retention.

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