• 靶点：
• TIS11D

• 简介：
• >>Cellular senescence

• 基因名称：
• ZFP36L2

• 蛋白名称：
• Zinc finger protein 36 C3H1 type-like 2

• Human Gene Id：
• 678

• Human Swiss Prot No：
• P47974

• Mouse Swiss Prot No：
• P23949

• 免疫原：
• The antiserum was produced against synthesized peptide derived from human TISD. AA range:207-256

• 特异性：
• TIS11D Polyclonal Antibody detects endogenous levels of TIS11D protein.

• 组成：
• Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• 来源：
• Polyclonal, Rabbit,IgG

• 稀释：
• WB 1:500 - 1:2000. IHC 1:100 - 1:300. ELISA: 1:20000.. IF 1:50-200

• 纯化工艺：
• The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

• 浓度：
• 1 mg/ml

• 储存：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• 其他名称：
• ZFP36L2;BRF2;ERF2;RNF162C;TIS11D;Zinc finger protein 36; C3H1 type-like 2;ZFP36-like 2;Butyrate response factor 2;EGF-response factor 2;ERF-2;Protein TIS11D

• 实测条带：
• 55kD

• 背景：
• This gene is a member of the TIS11 family of early response genes. Family members are induced by various agonists such as the phorbol ester TPA and the polypeptide mitogen EGF. The encoded protein contains a distinguishing putative zinc finger domain with a repeating cys-his motif. This putative nuclear transcription factor most likely functions in regulating the response to growth factors. [provided by RefSeq, Jul 2008],

• 功能：
• function:Probable regulatory protein involved in regulating the response to growth factors. RNA-binding protein that binds to 5'UUAUUUAUUU-3' core sequence. Binds to the class II AU-rich element (ARE) in the 3'-UTR of target mRNAs and promotes their deadenylation and degradation.,similarity:Contains 2 C3H1-type zinc fingers.,

• 细胞定位：
• Nucleus . Cytoplasm . Shuttles between the nucleus and the cytoplasm in a XPO1/CRM1-dependent manner. .

• 组织表达：
• Expressed mainly in the basal epidermal layer, weakly in the suprabasal epidermal layers (PubMed:27182009). Expressed in epidermal keratinocytes (at protein level) (PubMed:27182009).

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