Thrombin R Polyclonal Antibody
- 货号：YT4645
- 应用：WB;IHC;IF;ELISA
- 种属：Human;Rat;Mouse;
- 简介：
- >>Rap1 signaling pathway;>>Calcium signaling pathway;>>cAMP signaling pathway;>>Phospholipase D signaling pathway;>>Neuroactive ligand-receptor interaction;>>PI3K-Akt signaling pathway;>>Complement and coagulation cascades;>>Platelet activation;>>Regulation of actin cytoskeleton;>>Pathogenic Escherichia coli infection;>>Pathways in cancer
- 蛋白名称：
- Proteinase-activated receptor 1
- 免疫原：
- The antiserum was produced against synthesized peptide derived from human Thrombin Receptor. AA range:10-59
- 特异性：
- Thrombin R Polyclonal Antibody detects endogenous levels of Thrombin R protein.
- 组成：
- Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
- 来源：
- Polyclonal, Rabbit,IgG
- 稀释：
- WB 1:500 - 1:2000. ELISA: 1:5000.. IF 1:50-200
- 纯化工艺：
- The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
- 储存：
- -15°C to -25°C/1 year(Do not lower than -25°C)
- 其他名称：
- F2R;CF2R;PAR1;TR;Proteinase-activated receptor 1;PAR-1;Coagulation factor II receptor;Thrombin receptor
- 背景：
- Coagulation factor II receptor is a 7-transmembrane receptor involved in the regulation of thrombotic response. Proteolytic cleavage leads to the activation of the receptor. F2R is a G-protein coupled receptor family member. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2015],
- 功能：
- function:High affinity receptor for activated thrombin coupled to G proteins that stimulate phosphoinositide hydrolysis. May play a role in platelets activation and in vascular development.,PTM:A proteolytic cleavage generates a new N-terminus that functions as a tethered ligand.,PTM:Phosphorylated; probably mediating desensitization prior to the uncoupling and internalization of the receptor.,similarity:Belongs to the G-protein coupled receptor 1 family.,tissue specificity:Platelets and vascular endothelial cells.,
- 细胞定位：
- Cell membrane; Multi-pass membrane protein.
- 组织表达：
- Platelets and vascular endothelial cells.
- Western Blot analysis of various cells using Thrombin R Polyclonal Antibody
- Western blot analysis of lysates from HeLa cells, treated with Nocodazole 1ug/ml 18h, using Thrombin Receptor Antibody. The lane on the right is blocked with the synthesized peptide.
