TBX1 Polyclonal Antibody

    • 货号：YT4564
    • 应用：WB;IHC;IF;ELISA
    • 种属：Human;Mouse
      • 靶点：
      • TBX1
      • 基因名称：
      • TBX1
      • 蛋白名称：
      • T-box transcription factor TBX1
      • Human Gene Id：
      • 6899
      • Human Swiss Prot No：
      • O43435
      • Mouse Swiss Prot No：
      • P70323
      • 免疫原：
      • The antiserum was produced against synthesized peptide derived from human TBX1. AA range:311-360
      • 特异性：
      • TBX1 Polyclonal Antibody detects endogenous levels of TBX1 protein.
      • 组成：
      • Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
      • 来源：
      • Polyclonal, Rabbit,IgG
      • 稀释：
      • WB 1:500 - 1:2000. IHC 1:100 - 1:300. IF 1:200 - 1:1000. ELISA: 1:20000. Not yet tested in other applications.
      • 纯化工艺：
      • The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
      • 浓度：
      • 1 mg/ml
      • 储存：
      • -15°C to -25°C/1 year(Do not lower than -25°C)
      • 其他名称：
      • TBX1;T-box transcription factor TBX1;T-box protein 1;Testis-specific T-box protein
      • 实测条带：
      • 43kD
      • 背景：
      • This gene is a member of a phylogenetically conserved family of genes that share a common DNA-binding domain, the T-box. T-box genes encode transcription factors involved in the regulation of developmental processes. This gene product shares 98% amino acid sequence identity with the mouse ortholog. DiGeorge syndrome (DGS)/velocardiofacial syndrome (VCFS), a common congenital disorder characterized by neural-crest-related developmental defects, has been associated with deletions of chromosome 22q11.2, where this gene has been mapped. Studies using mouse models of DiGeorge syndrome suggest a major role for this gene in the molecular etiology of DGS/VCFS. Several alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Jul 2008],
      • 功能：
      • disease:Defects in TBX1 are a cause of conotruncal heart malformations (CTHM) [MIM:217095]. CTHM consist of cardiac outflow tract defects, such as tetralogy of Fallot, pulmonary atresia, double-outlet right ventricle, truncus arteriosus communis, and aortic arch anomalies.,disease:Defects in TBX1 are a cause of DiGeorge syndrome (DGS) [MIM:188400].,disease:Defects in TBX1 are a cause of velocardiofacial syndrome (VCFS) [MIM:192430].,disease:Haploinsufficiency of the TBX1 gene is responsible for most of the physical malformations present in DiGeorge syndrome (DGS) and velocardiofacial syndrome (VCFS) [MIM:188400, 192430]. DGS is characterized by the association of several malformations: hypoplastic thymus and parathyroid glands, congenital conotruncal cardiopathy, and a subtle but characteristic facial dysmorphology. VCFS is marked by the association of congenital conotruncal heart defect
      • 细胞定位：
      • Nucleus .
      • 组织表达：
      • Skeletal muscle,Testis,
      • 产品图片
      • Western Blot analysis of various cells using TBX1 Polyclonal Antibody cells nucleus extracted by Minute TM Cytoplasmic and Nuclear Fractionation kit (SC-003,Inventbiotech,MN,USA).
      • Immunofluorescence analysis of A549 cells, using TBX1 Antibody. The picture on the right is blocked with the synthesized peptide.
      • Western blot analysis of lysates from COLO205 cells, using TBX1 Antibody. The lane on the right is blocked with the synthesized peptide.
      • Western blot analysis of the lysates from 293 cells using TBX1 antibody.
      • Immunohistochemical analysis of paraffin-embedded human brain tumor. 1, Antibody was diluted at 1:200(4° overnight). 2, Tris-EDTA,pH9.0 was used for antigen retrieval. 3,Secondary antibody was diluted at 1:200(room temperature, 45min).

      相关报价

      • 货号：
      • YT4564
      • 规格：
      • 40μL / 100μL / 200μL
      • 价格：
      • ¥960 / 2300 / 3780
      • 货期：
      • 预计发货时间为
        2024-11-26
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