• 靶点：
• Synuclein-β

• 基因名称：
• SNCB

• 蛋白名称：
• Beta-synuclein

• Human Gene Id：
• 6620

• Human Swiss Prot No：
• Q16143

• Mouse Gene Id：
• 104069

• Mouse Swiss Prot No：
• Q91ZZ3

• Rat Gene Id：
• 113893

• Rat Swiss Prot No：
• Q63754

• 免疫原：
• The antiserum was produced against synthesized peptide derived from human Synuclein beta. AA range:85-134

• 特异性：
• Synuclein-β Polyclonal Antibody detects endogenous levels of Synuclein-β protein.

• 组成：
• Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• 来源：
• Polyclonal, Rabbit,IgG

• 稀释：
• WB 1:500 - 1:2000. IHC 1:100 - 1:300. IF 1:200 - 1:1000. ELISA: 1:20000. Not yet tested in other applications.

• 纯化工艺：
• The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

• 浓度：
• 1 mg/ml

• 储存：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• 其他名称：
• SNCB;Beta-synuclein

• 实测条带：
• 14kD

• 背景：
• This gene encodes a member of a small family of proteins that inhibit phospholipase D2 and may function in neuronal plasticity. The encoded protein is abundant in lesions of patients with Alzheimer disease. A mutation in this gene was found in individuals with dementia with Lewy bodies. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2015],

• 功能：
• disease:Brain iron accumulation type 1 (NBIA1, also called Hallervorden-Spatz syndrome), a rare neuroaxonal dystrophy, is histologically characterized by axonal spheroids, iron deposition, Lewy body (LB)-like intraneuronal inclusions, glial inclusions and neurofibrillary tangles. SNCB is found in spheroids but not in inclusions.,function:Non-amyloid component of senile plaques found in Alzheimer disease. Could act as a regulator of SNCA aggregation process. Protects neurons from staurosporine and 6-hydroxy dopamine (6OHDA)-stimulated caspase activation in a TP53/p53-dependent manner. Contributes to restore the SNCA anti-apoptotic function abolished by 6OHDA. Not found in the Lewy bodies associated with Parkinson disease.,PTM:Phosphorylated. Phosphorylation by G-protein coupled receptor kinases (GRK) is more efficient than phosphorylation by CK1, CK2 and CaM-kinase II.,similarity:Belongs

• 细胞定位：
• Cytoplasm.

• 组织表达：
• Expressed predominantly in brain; concentrated in presynaptic nerve terminals.

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