• 靶点：
• Pki α

• 简介：
• >>Alcoholism

• 基因名称：
• PKIA

• 蛋白名称：
• cAMP-dependent protein kinase inhibitor alpha

• Human Gene Id：
• 5569

• Human Swiss Prot No：
• P61925

• Mouse Gene Id：
• 18767

• Mouse Swiss Prot No：
• P63248

• Rat Gene Id：
• 114906

• Rat Swiss Prot No：
• P63249

• 免疫原：
• The antiserum was produced against synthesized peptide derived from human IPKA. AA range:10-59

• 特异性：
• Pki α Polyclonal Antibody detects endogenous levels of Pki α protein.

• 组成：
• Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• 来源：
• Polyclonal, Rabbit,IgG

• 稀释：
• IHC 1:100 - 1:300. IF 1:200 - 1:1000. ELISA: 1:20000. Not yet tested in other applications.

• 纯化工艺：
• The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

• 浓度：
• 1 mg/ml

• 储存：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• 其他名称：
• PKIA;PRKACN1;cAMP-dependent protein kinase inhibitor alpha;PKI-alpha;cAMP-dependent protein kinase inhibitor; muscle/brain isoform

• 分子量：
• 8kD

• 背景：
• The protein encoded by this gene is a member of the cAMP-dependent protein kinase (PKA) inhibitor family. This protein was demonstrated to interact with and inhibit the activities of both C alpha and C beta catalytic subunits of the PKA. Alternatively spliced transcript variants encoding the same protein have been reported. [provided by RefSeq, Jul 2008],

• 功能：
• function:Extremely potent competitive inhibitor of cAMP-dependent protein kinase activity, this protein interacts with the catalytic subunit of the enzyme after the cAMP-induced dissociation of its regulatory chains.,miscellaneous:The inhibitory site contains regions very similar to the hinge regions (sites that directly interact with the enzyme active site) and "pseudosubstrate site" of the regulatory chains; but, unlike these chains, PKI does not contain cAMP-binding sites. The arginine residues within the inhibitory site are essential for inhibition and recognition of the enzyme active site.,similarity:Belongs to the PKI family.,

• 细胞定位：
• nucleus,cytoplasm,

• 组织表达：
• Skeletal muscle,

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