• 靶点：
• PEDF

• 简介：
• >>Wnt signaling pathway

• 基因名称：
• SERPINF1

• 蛋白名称：
• Pigment epithelium-derived factor

• Human Gene Id：
• 5176

• Human Swiss Prot No：
• P36955

• Mouse Gene Id：
• 20317

• Mouse Swiss Prot No：
• P97298

• 免疫原：
• The antiserum was produced against synthesized peptide derived from human PEDF. AA range:258-307

• 特异性：
• PEDF Polyclonal Antibody detects endogenous levels of PEDF protein.

• 组成：
• Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• 来源：
• Polyclonal, Rabbit,IgG

• 稀释：
• WB 1:500 - 1:2000. IHC: 1:100-300 ELISA: 1:20000. IF 1:100-300 Not yet tested in other applications.

• 纯化工艺：
• The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

• 浓度：
• 1 mg/ml

• 储存：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• 其他名称：
• SERPINF1;PEDF;PIG35;Pigment epithelium-derived factor;PEDF;Cell proliferation-inducing gene 35 protein;EPC-1;Serpin F1

• 实测条带：
• 46kD

• 背景：
• This gene encodes a member of the serpin family that does not display the serine protease inhibitory activity shown by many of the other serpin proteins. The encoded protein is secreted and strongly inhibits angiogenesis. In addition, this protein is a neurotrophic factor involved in neuronal differentiation in retinoblastoma cells. Mutations in this gene were found in individuals with osteogenesis imperfecta, type VI. [provided by RefSeq, Aug 2016],

• 功能：
• developmental stage:Expressed in quiescent cells.,domain:The N-terminal (AA 44-121) exhibits neurite outgrowth-inducing activity. The C-terminal exposed loop (AA 382-418) is essential for serpin activity.,function:Neurotrophic protein; induces extensive neuronal differentiation in retinoblastoma cells. Potent inhibitor of angiogenesis. As it does not undergo the S (stressed) to R (relaxed) conformational transition characteristic of active serpins, it exhibits no serine protease inhibitory activity.,PTM:The N-terminus is blocked. Extracellular phosphorylation enhances antiangiogenic activity.,similarity:Belongs to the serpin family.,subcellular location:Enriched in stage I melanosomes.,tissue specificity:Retinal pigment epithelial cells and blood plasma.,

• 细胞定位：
• Secreted . Melanosome . Enriched in stage I melanosomes.

• 组织表达：
• Retinal pigment epithelial cells and blood plasma.

The Role of RAD6B and PEDF in Retinal Degeneration. NEUROSCIENCE Neuroscience. 2022 Jan;480:19 WB，IHC Mouse 1:10000,1:200 Eyeball，Retina
货号：YT3658

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