• 靶点：
• mtTFA

• 简介：
• >>Apelin signaling pathway;>>Huntington disease

• 基因名称：
• TFAM

• 蛋白名称：
• Transcription factor A mitochondrial

• Human Gene Id：
• 7019

• Human Swiss Prot No：
• Q00059

• Mouse Swiss Prot No：
• P40630

• 免疫原：
• The antiserum was produced against synthesized peptide derived from human TFAM. AA range:131-180

• 特异性：
• mtTFA Polyclonal Antibody detects endogenous levels of mtTFA protein.

• 组成：
• Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• 来源：
• Polyclonal, Rabbit,IgG

• 稀释：
• WB 1:500-2000;IHC 1:100 - 1:300. IF 1:200 - 1:1000. ELISA: 1:20000. Not yet tested in other applications.

• 纯化工艺：
• The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

• 浓度：
• 1 mg/ml

• 储存：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• 其他名称：
• TFAM;TCF6;TCF6L2;Transcription factor A; mitochondrial;mtTFA;Mitochondrial transcription factor 1;MtTF1;Transcription factor 6;TCF-6;Transcription factor 6-like 2

• 实测条带：
• 22kd

• 背景：
• This gene encodes a key mitochondrial transcription factor containing two high mobility group motifs. The encoded protein also functions in mitochondrial DNA replication and repair. Sequence polymorphisms in this gene are associated with Alzheimer's and Parkinson's diseases. There are pseudogenes for this gene on chromosomes 6, 7, and 11. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2012],

• 功能：
• function:Involved in mitochondrial transcription regulation. Required for accurate and efficient promoter recognition by the mitochondrial RNA polymerase. Activates transcription by binding immediately upstream of transcriptional start sites. Is able to unwind and bend DNA.,similarity:Contains 2 HMG box DNA-binding domains.,subunit:Interacts with TFB1M and TFB2M.,

• 细胞定位：
• Mitochondrion . Mitochondrion matrix, mitochondrion nucleoid .

• 组织表达：
• Lymphocyte,Pooled,Uterus,

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