• 靶点：
• IGF-I

• 基因名称：
• IGF1

• 蛋白名称：
• Insulin-like growth factor I

• Human Gene Id：
• 3479

• Human Swiss Prot No：
• P05019

• Mouse Gene Id：
• 16000

• Rat Gene Id：
• 24482

• Rat Swiss Prot No：
• P08025

• 免疫原：
• The antiserum was produced against synthesized peptide derived from human IGF-I. AA range:100-149

• 特异性：
• IGF-I Polyclonal Antibody detects endogenous levels of IGF-I protein.

• 组成：
• Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• 来源：
• Polyclonal, Rabbit,IgG

• 稀释：
• IHC 1:100 - 1:300. ELISA: 1:10000.. IF 1:50-200

• 纯化工艺：
• The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

• 浓度：
• 1 mg/ml

• 储存：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• 其他名称：
• IBP1;IGF-IA;IGF1A;IGFI;insulin-like growth factor 1;insulin-like growth factor IA;mechano growth factor;MGF;somatomedin C

• 分子量：
• 17-22kD

• 背景：
• The protein encoded by this gene is similar to insulin in function and structure and is a member of a family of proteins involved in mediating growth and development. The encoded protein is processed from a precursor, bound by a specific receptor, and secreted. Defects in this gene are a cause of insulin-like growth factor I deficiency. Alternative splicing results in multiple transcript variants encoding different isoforms that may undergo similar processing to generate mature protein. [provided by RefSeq, Sep 2015],

• 功能：
• disease:Defects in IGF1 are the cause of insulin-like growth factor I deficiency (IGF1 deficiency) [MIM:608747]. IGF1 deficiency is an autosomal recessive disorder characterized by growth retardation, sensorineural deafness and mental retardation.,function:The insulin-like growth factors, isolated from plasma, are structurally and functionally related to insulin but have a much higher growth-promoting activity.,online information:Insulin-like growth factor 1 entry,online information:The Singapore human mutation and polymorphism database,similarity:Belongs to the insulin family.,

• 细胞定位：
• extracellular region,extracellular space,plasma membrane,insulin-like growth factor binding protein complex,platelet alpha granule lumen,alphav-beta3 integrin-IGF-1-IGF1R complex,insulin-like growth factor ternary complex,exocytic vesicle,

• 组织表达：
• Brain,Liver,PCR rescued clones,

Mechanism of NO2-induced migraine in rats: The exploration of the role of miR-653-3p/IGF1 axis JOURNAL OF HAZARDOUS MATERIALS Shuzi Ye WB,IF Rat 1:1000,1:500 trigeminal ganglion primary trigeminal ganglion neurons (PTGNs)
货号：YT2288

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