- 靶点：
- Frizzled-1
- 简介：
- >>mTOR signaling pathway;>>Wnt signaling pathway;>>Hippo signaling pathway;>>Signaling pathways regulating pluripotency of stem cells;>>Melanogenesis;>>Cushing syndrome;>>Alzheimer disease;>>Pathways of neurodegeneration - multiple diseases;>>Human papillomavirus infection;>>Pathways in cancer;>>Proteoglycans in cancer;>>Basal cell carcinoma;>>Breast cancer;>>Hepatocellular carcinoma;>>Gastric cancer
- 基因名称：
- FZD1
- 蛋白名称：
- Frizzled-1
- Human Gene Id：
- 8321
- Human Swiss Prot No：
- Q9UP38
- Mouse Swiss Prot No：
- O70421
- 免疫原：
- The antiserum was produced against synthesized peptide derived from human FZD1. AA range:15-64
- 特异性：
- Frizzled-1 Polyclonal Antibody detects endogenous levels of Frizzled-1 protein.
- 组成：
- Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
- 来源：
- Polyclonal, Rabbit,IgG
- 稀释：
- WB 1:500 - 1:2000. IF 1:200 - 1:1000. ELISA: 1:5000. Not yet tested in other applications.
- 纯化工艺：
- The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
- 浓度：
- 1 mg/ml
- 储存：
- -15°C to -25°C/1 year(Do not lower than -25°C)
- 其他名称：
- FZD1;Frizzled-1;Fz-1;hFz1;FzE1
- 实测条带：
- 71kD
- 背景：
- frizzled class receptor 1(FZD1) Homo sapiens Members of the 'frizzled' gene family encode 7-transmembrane domain proteins that are receptors for Wnt signaling proteins. The FZD1 protein contains a signal peptide, a cysteine-rich domain in the N-terminal extracellular region, 7 transmembrane domains, and a C-terminal PDZ domain-binding motif. The FZD1 transcript is expressed in various tissues. [provided by RefSeq, Jul 2008],
- 功能：
- domain:Lys-Thr-X-X-X-Trp motif is involved in the activation of the Wnt/beta-catenin signaling pathway.,domain:The FZ domain is involved in binding with Wnt ligands.,function:Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. May be involved in transduction and intercellular transmission of polarity information during tissue morphog
- 细胞定位：
- Cell membrane ; Multi-pass membrane protein .
- 组织表达：
- Expressed in adult heart, placenta, lung, kidney, pancreas, prostate, and ovary and in fetal lung and kidney.
Pollen developmental defects in ZD-CMS rice line explored by cytological, molecular and proteomic approaches. Journal of Proteomics 2014 May 28 WB Rice florets
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- Antibody-FAQs
- 产品图片
- Western Blot analysis of various cells using Frizzled-1 Polyclonal Antibody
- Western blot analysis of lysates from HeLa and COLO205 cells, using FZD1 Antibody. The lane on the right is blocked with the synthesized peptide.
- Western blot analysis of the lysates from HT-29 cells using FZD1 antibody.
