• 靶点：
• FoxK1

• 基因名称：
• FOXK1

• 蛋白名称：
• Forkhead box protein K1

• Human Gene Id：
• 221937

• Human Swiss Prot No：
• P85037

• Mouse Gene Id：
• 17425

• Mouse Swiss Prot No：
• P42128

• 免疫原：
• The antiserum was produced against synthesized peptide derived from human FOXK1. AA range:681-730

• 特异性：
• FoxK1 Polyclonal Antibody detects endogenous levels of FoxK1 protein.

• 组成：
• Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• 来源：
• Polyclonal, Rabbit,IgG

• 稀释：
• WB 1:500 - 1:2000. IHC 1:100 - 1:300. ELISA: 1:20000.. IF 1:50-200

• 纯化工艺：
• The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

• 浓度：
• 1 mg/ml

• 储存：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• 其他名称：
• FOXK1;MNF;Forkhead box protein K1;Myocyte nuclear factor;MNF

• 实测条带：
• 78kD

• 背景：
• function:Transcriptional regulator that binds to the upstream enhancer region (CCAC box) of myoglobin gene. Has a role in myogenic differentiation and in remodeling processes of adult muscles that occur in response to physiological stimuli.,PTM:Phosphorylated.,similarity:Contains 1 FHA domain.,similarity:Contains 1 fork-head DNA-binding domain.,subunit:Interacts with SIN3B to form a complex which represses transcription.,tissue specificity:Expressed both developing and adult tissues. In adults, significant expression is seen in tumors of the brain, colon and lymph node.,

• 功能：
• function:Transcriptional regulator that binds to the upstream enhancer region (CCAC box) of myoglobin gene. Has a role in myogenic differentiation and in remodeling processes of adult muscles that occur in response to physiological stimuli.,PTM:Phosphorylated.,similarity:Contains 1 FHA domain.,similarity:Contains 1 fork-head DNA-binding domain.,subunit:Interacts with SIN3B to form a complex which represses transcription.,tissue specificity:Expressed both developing and adult tissues. In adults, significant expression is seen in tumors of the brain, colon and lymph node.,

• 细胞定位：
• Nucleus . Cytoplasm . Translocation to the nucleus is regulated by phosphorylation: phosphorylation by GSK3 (GSK3A or GSK3B) promotes interaction with 14-3-3 proteins and sequestration in the cytoplasm. Dephosphorylation promotes translocation to the nucleus (By similarity). Accumulates in the nucleus upon viral infection (PubMed:25852164). .

• 组织表达：
• Expressed both developing and adult tissues (PubMed:15289879). In adults, significant expression is seen in tumors of the brain, colon and lymph node (PubMed:15289879).

FOXK1 upregulation is correlated with tumor progression and tumor associated macrophages infiltration in renal cell carcinoma. MOLECULAR CARCINOGENESIS Jianqing Ye WB，IHC Human RCC(renal cell carcinoma) tumor tissues 769-P cell,786-O cell
货号：YT1753

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