• 靶点：
• AR-β3

• 简介：
• >>Calcium signaling pathway;>>cGMP-PKG signaling pathway;>>Neuroactive ligand-receptor interaction;>>Thermogenesis;>>Regulation of lipolysis in adipocytes;>>Renin secretion;>>Salivary secretion;>>Chemical carcinogenesis - receptor activation

• 基因名称：
• ADRB3

• 蛋白名称：
• Beta-3 adrenergic receptor

• Human Gene Id：
• 155

• Human Swiss Prot No：
• P13945

• Mouse Gene Id：
• 11556

• Mouse Swiss Prot No：
• P25962

• Rat Gene Id：
• 25645

• Rat Swiss Prot No：
• P26255

• 免疫原：
• The antiserum was produced against synthesized peptide derived from human ADRB3. AA range:250-299

• 特异性：
• AR-β3 Polyclonal Antibody detects endogenous levels of AR-β3 protein.

• 组成：
• Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• 来源：
• Polyclonal, Rabbit,IgG

• 稀释：
• WB 1:500-2000 IF 1:100-300 ELISA 1:5000-20000 Not yet tested in other applications.

• 纯化工艺：
• The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

• 浓度：
• 1 mg/ml

• 储存：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• 其他名称：
• ADRB3;ADRB3R;B3AR;Beta-3 adrenergic receptor;Beta-3 adrenoreceptor;Beta-3 adrenoceptor

• 实测条带：
• 36kD

• 背景：
• The protein encoded by this gene belongs to the family of beta adrenergic receptors, which mediate catecholamine-induced activation of adenylate cyclase through the action of G proteins. This receptor is located mainly in the adipose tissue and is involved in the regulation of lipolysis and thermogenesis. [provided by RefSeq, Feb 2009],

• 功能：
• function:Beta-adrenergic receptors mediate the catecholamine-induced activation of adenylate cyclase through the action of G proteins. Beta-3 is involved in the regulation of lipolysis and thermogenesis.,polymorphism:The variant Arg-64 seems to be associated with weight gain (obesity) and to is also associated with susceptibility to non-insulin-dependent diabetes mellitus (NIDDM).,similarity:Belongs to the G-protein coupled receptor 1 family.,tissue specificity:Expressed mainly in adipose tissues.,

• 细胞定位：
• Cell membrane; Multi-pass membrane protein.

• 组织表达：
• Expressed mainly in adipose tissues.

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Remodelling the inguinal adipose sensory system to switch on the furnace: Electroacupuncture stimulation induces brown adipose thermogenesis DIABETES OBESITY & METABOLISM Mengjiang Lu WB Mouse 1:1000 interscapular brown adipose tissue (iBAT)
货号：YT0363

Xiasangju alleviate metabolic syndrome by enhancing noradrenaline biosynthesis and activating brown adipose tissue Xiasangju alleviate metabolic syndrome through gut microbiota-adipose tissue axis modulation to enhance noradrenaline-mediated energy metabolism Frontiers in Pharmacology He Changhao WB Rat 1:1000 brown adipose tissue (BAT)
货号：YT0363

Neuregulin4-ErbB4 signalling pathway is driven by electroacupuncture stimulation to remodel brown adipose tissue innervation DIABETES OBESITY & METABOLISM Ziwei Yu WB Mouse 1:1000 interscapular brown adipose tissue(iBAT)
货号：YT0363

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