- 靶点:
- ApoER2
- 基因名称:
- LRP8
- 蛋白名称:
- Low-density lipoprotein receptor-related protein 8
- Human Gene Id:
- 55911
- Human Swiss Prot No:
- Q14114
- Mouse Swiss Prot No:
- Q924X6
- 免疫原:
- The antiserum was produced against synthesized peptide derived from human LRP8. AA range:451-500
- 特异性:
- ApoER2 Polyclonal Antibody detects endogenous levels of ApoER2 protein.
- 组成:
- Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
- 来源:
- Polyclonal, Rabbit,IgG
- 稀释:
- WB 1:500 - 1:2000. ELISA: 1:40000. Not yet tested in other applications.
- 纯化工艺:
- The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
- 浓度:
- 1 mg/ml
- 储存:
- -15°C to -25°C/1 year(Do not lower than -25°C)
- 其他名称:
- LRP8;APOER2;Low-density lipoprotein receptor-related protein 8;LRP-8;Apolipoprotein E receptor 2
- 实测条带:
- 100kD
- 背景:
- This gene encodes a member of the low density lipoprotein receptor (LDLR) family. Low density lipoprotein receptors are cell surface proteins that play roles in both signal transduction and receptor-mediated endocytosis of specific ligands for lysosomal degradation. The encoded protein plays a critical role in the migration of neurons during development by mediating Reelin signaling, and also functions as a receptor for the cholesterol transport protein apolipoprotein E. Expression of this gene may be a marker for major depressive disorder. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jun 2011],
- 功能:
- alternative products:Additional isoforms seem to exist. No differences were observed in the pattern splicing between control and Alzheimer brains,disease:Genetic variation in LRP8 is associated with susceptibility to myocardial infarction type 1 [MIM:608446]. Atherosclerotic coronary artery disease (CAD) and myocardial infarction (MI) are complex traits that account for the leading cause of death in the Western world heart disease.,domain:The cytoplasmic domain is involved in the binding of DAB1 and in the recruitment of JNK-interacting proteins. Isoforms, which lack part of the cytoplasmic domain, are unable to recruit members of the family of JNK interacting proteins (JIP) to the cytoplasmic tail.,function:Cell surface receptor for Reelin (RELN) and apolipoprotein E (apoE)-containing ligands. LRP8 participates in transmitting the extracellular Reelin signal to intracellular signaling p
- 细胞定位:
- Cell membrane ; Single-pass type I membrane protein . Secreted . Isoforms that contain the exon coding for a furin-type cleavage site are proteolytically processed, leading to a secreted receptor fragment. .
- 组织表达:
- Expressed mainly in brain and placenta. Also expressed in platelets and megakaryocytic cells. Not expressed in the liver.
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- 产品图片
- Western blot analysis of the lysates from HeLa cells using LRP8 antibody.