• 靶点：
• LDHA

• 简介：
• >>Glycolysis / Gluconeogenesis;>>Cysteine and methionine metabolism;>>Pyruvate metabolism;>>Propanoate metabolism;>>Metabolic pathways;>>HIF-1 signaling pathway;>>Glucagon signaling pathway;>>Central carbon metabolism in cancer

• 基因名称：
• LDHA PIG19

• 蛋白名称：
• LDHA (Tyr10)

• Human Gene Id：
• 3939

• Human Swiss Prot No：
• P00338

• Mouse Gene Id：
• 16828

• Mouse Swiss Prot No：
• P06151

• Rat Gene Id：
• 24533

• Rat Swiss Prot No：
• P04642

• 免疫原：
• Synthesized phosho peptide around human LDHA (Tyr10)

• 特异性：
• This antibody detects endogenous levels of Human Mouse Rat LDHA (phospho-Tyr10)

• 组成：
• Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• 来源：
• Polyclonal, Rabbit,IgG

• 稀释：
• WB 1:500-2000;IHC 1:50-300; ELISA 2000-20000

• 纯化工艺：
• The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.

• 浓度：
• 1 mg/ml

• 储存：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• 其他名称：
• L-lactate dehydrogenase A chain (LDH-A) (EC 1.1.1.27) (Cell proliferation-inducing gene 19 protein) (LDH muscle subunit) (LDH-M) (Renal carcinoma antigen NY-REN-59)

• 实测条带：
• 36kD

• 背景：
• The protein encoded by this gene catalyzes the conversion of L-lactate and NAD to pyruvate and NADH in the final step of anaerobic glycolysis. The protein is found predominantly in muscle tissue and belongs to the lactate dehydrogenase family. Mutations in this gene have been linked to exertional myoglobinuria. Multiple transcript variants encoding different isoforms have been found for this gene. The human genome contains several non-transcribed pseudogenes of this gene. [provided by RefSeq, Sep 2008],

• 功能：
• catalytic activity:(S)-lactate + NAD(+) = pyruvate + NADH.,caution:The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.,disease:Defects in LDHA are a cause of exertional myoglobinuria.,online information:Lactate dehydrogenase entry,pathway:Fermentation; pyruvate fermentation to lactate; (S)-lactate from pyruvate: step 1/1.,similarity:Belongs to the LDH/MDH superfamily.,similarity:Belongs to the LDH/MDH superfamily. LDH family.,subunit:Homotetramer.,

• 细胞定位：
• Cytoplasm.

• 组织表达：
• Predominantly expressed in anaerobic tissues such as skeletal muscle and liver.

Trophoblast-derived Lactic Acid Orchestrates Decidual Macrophage Differentiation via SRC/LDHA Signaling in Early Pregnancy Int J Biol Sci. 2022; 18(2): 599–616. WB Human decidua
货号：YP1385

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