• 靶点：
• GRK 2

• 简介：
• >>Chemokine signaling pathway;>>Endocytosis;>>Hedgehog signaling pathway;>>Glutamatergic synapse;>>Olfactory transduction;>>Morphine addiction

• 基因名称：
• ADRBK1 BARK BARK1 GRK2

• 蛋白名称：
• Beta-adrenergic receptor kinase 1 (Beta-ARK-1) (EC 2.7.11.15) (G-protein coupled receptor kinase 2)

• Human Gene Id：
• 156

• Human Swiss Prot No：
• P25098

• Mouse Swiss Prot No：
• Q99MK8

• Rat Gene Id：
• 25238

• Rat Swiss Prot No：
• P26817

• 免疫原：
• Synthesized phospho derived from human GRK2 (Phospho-Ser685)

• 特异性：
• This detects endogenous levels of GRK2 (Phospho-Ser685)

• 组成：
• Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• 来源：
• Polyclonal, Rabbit,IgG

• 稀释：
• WB 1:500-2000, ELISA 1:10000-20000

• 纯化工艺：
• The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

• 浓度：
• 1 mg/ml

• 储存：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• 其他名称：
• Beta-adrenergic receptor kinase 1 (Beta-ARK-1) (EC 2.7.11.15) (G-protein coupled receptor kinase 2)

• 实测条带：
• 80kD

• 背景：
• The product of this gene phosphorylates the beta-2-adrenergic receptor and appears to mediate agonist-specific desensitization observed at high agonist concentrations. This protein is an ubiquitous cytosolic enzyme that specifically phosphorylates the activated form of the beta-adrenergic and related G-protein-coupled receptors. Abnormal coupling of beta-adrenergic receptor to G protein is involved in the pathogenesis of the failing heart. [provided by RefSeq, Jul 2008],

• 功能：
• catalytic activity:ATP + [beta-adrenergic receptor] = ADP + [beta-adrenergic receptor] phosphate.,catalytic activity:ATP + a protein = ADP + a phosphoprotein.,function:Specifically phosphorylates the agonist-occupied form of the beta-adrenergic and closely related receptors, probably inducing a desensitization of them.,online information:Beta adrenergic receptor kinase entry,similarity:Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily.,similarity:Contains 1 AGC-kinase C-terminal domain.,similarity:Contains 1 PH domain.,similarity:Contains 1 protein kinase domain.,similarity:Contains 1 RGS domain.,subunit:Interacts with GIT1 (By similarity). Interacts with, and phosphorylates chemokine-stimulated CCR5.,tissue specificity:Expressed in peripheral blood leukocytes.,

• 细胞定位：
• Cytoplasm . Cell membrane . Cell junction, synapse, postsynapse . Cell junction, synapse, presynapse .

• 组织表达：
• Expressed in peripheral blood leukocytes.

Paroxetine alleviates dendritic cell and T lymphocyte activation via GRK2-mediated PI3K–AKT signaling in rheumatoid arthritis CHINESE MEDICAL JOURNAL Liu Tingting WB Mouse,Human spleen tissue Bone marrow dendritic cell(BMDC),peripheral blood lymphocytes (PBLs)
货号：YP1225

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