• 靶点：
• Rho GDIα

• 简介：
• >>Neurotrophin signaling pathway;>>Vasopressin-regulated water reabsorption

• 基因名称：
• ARHGDIA

• 蛋白名称：
• Rho GDP-dissociation inhibitor 1

• Human Gene Id：
• 396

• Human Swiss Prot No：
• P52565

• Mouse Gene Id：
• 192662

• Mouse Swiss Prot No：
• Q99PT1

• Rat Gene Id：
• 360678

• Rat Swiss Prot No：
• Q5XI73

• 免疫原：
• The antiserum was produced against synthesized peptide derived from human ARHGDIA around the phosphorylation site of Ser174. AA range:140-189

• 特异性：
• Phospho-Rho GDIα (S174) Polyclonal Antibody detects endogenous levels of Rho GDIα protein only when phosphorylated at S174.

• 组成：
• Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• 来源：
• Polyclonal, Rabbit,IgG

• 稀释：
• WB 1:500 - 1:2000. IHC 1:100 - 1:300. ELISA: 1:20000.. IF 1:50-200

• 纯化工艺：
• The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

• 浓度：
• 1 mg/ml

• 储存：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• 其他名称：
• ARHGDIA;GDIA1;Rho GDP-dissociation inhibitor 1;Rho GDI 1;Rho-GDI alpha

• 实测条带：
• 23kD

• 背景：
• This gene encodes a protein that plays a key role in the regulation of signaling through Rho GTPases. The encoded protein inhibits the disassociation of Rho family members from GDP (guanine diphosphate), thereby maintaining these factors in an inactive state. Activity of this protein is important in a variety of cellular processes, and expression of this gene may be altered in tumors. Mutations in this gene have been found in individuals with nephrotic syndrome, type 8. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014],

• 功能：
• function:Regulates the GDP/GTP exchange reaction of the Rho proteins by inhibiting the dissociation of GDP from them, and the subsequent binding of GTP to them.,similarity:Belongs to the Rho GDI family.,subunit:Monomer.,

• 细胞定位：
• Cytoplasm .

• 组织表达：
• Brain,Cajal-Retzius cell,Colon,Epithelium,Fetal brain cortex,Lung,M

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