• 靶点：
• 4.1R

• 基因名称：
• EPB41

• 蛋白名称：
• Protein 4.1

• Human Gene Id：
• 2035

• Human Swiss Prot No：
• P11171

• Mouse Gene Id：
• 269587

• Mouse Swiss Prot No：
• P48193

• 免疫原：
• The antiserum was produced against synthesized peptide derived from human EPB41 around the phosphorylation site of Tyr660/418. AA range:626-675

• 特异性：
• Phospho-4.1R (Y660) Polyclonal Antibody detects endogenous levels of 4.1R protein only when phosphorylated at Y660.

• 组成：
• Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• 来源：
• Polyclonal, Rabbit,IgG

• 稀释：
• WB 1:500 - 1:2000. IHC 1:100 - 1:300. ELISA: 1:5000.. IF 1:50-200

• 纯化工艺：
• The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

• 浓度：
• 1 mg/ml

• 储存：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• 其他名称：
• EPB41;E41P;Protein 4.1;P4.1;4.1R;Band 4.1;EPB4.1

• 实测条带：
• 60kD

• 背景：
• The protein encoded by this gene, together with spectrin and actin, constitute the red cell membrane cytoskeletal network. This complex plays a critical role in erythrocyte shape and deformability. Mutations in this gene are associated with type 1 elliptocytosis (EL1). Alternatively spliced transcript variants encoding different isoforms have been described for this gene.[provided by RefSeq, Oct 2009],

• 功能：
• disease:Defects in EPB41 are a cause of hereditary pyropoikilocytosis (HPP) [MIM:266140]. HPP is an autosomal recessive hematologic disorder characterized by hemolytic anemia, microspherocytosis, poikilocytosis, and an unusual thermal sensitivity of red cells.,disease:Defects in EPB41 are the cause of elliptocytosis type 1 (EL1) [MIM:611804]. EL1 is a Rhesus-linked form of hereditary elliptocytosis, a genetically heterogeneous, autosomal dominant, hematologic disorder. It is characterized by variable hemolytic anemia and elliptical or oval red cell shape.,function:Protein 4.1 is a major structural element of the erythrocyte membrane skeleton. It plays a key role in regulating membrane physical properties of mechanical stability and deformability by stabilizing spectrin-actin interaction. Recruits DLG1 to membranes.,PTM:O-glycosylated; contains N-acetylglucosamine side chains in the C-ter

• 细胞定位：
• Cytoplasm, cytoskeleton . Cytoplasm, cell cortex . Nucleus .

• 组织表达：
• Brain,PCR rescued clones,Reticulocyte,Spleen,

Accurate prediction of drug-induced heterogeneous response of red cell in vivo using a gravity-driven flow cytometry based on a microfluidic chip ANALYTICA CHIMICA ACTA Shuwen Liu WB Human
货号：YP0468

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