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NRG4 Polyclonal Antibody

货号：YN2440
应用：WB;ELISA
种属：Human;Mouse

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靶点：
NRG4

简介：
>>ErbB signaling pathway;>>Amyotrophic lateral sclerosis

基因名称：
NRG4

蛋白名称：
Pro-neuregulin-4, membrane-bound isoform (Pro-NRG4) [Cleaved into: Neuregulin-4 (NRG-4)]

Human Gene Id：
145957

Human Swiss Prot No：
Q8WWG1

Mouse Swiss Prot No：
Q9WTX4

免疫原：
Synthesized peptide derived from human protein . at AA range: 11-60

特异性：
NRG4 Polyclonal Antibody detects endogenous levels of protein.

组成：
Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.

来源：
Polyclonal, Rabbit,IgG

稀释：
WB 1:500-2000 ELISA 1:5000-20000

纯化工艺：
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

浓度：
1 mg/ml

储存：
-15°C to -25°C/1 year(Do not lower than -25°C)

实测条带：
12kD

背景：
The neuregulins, including NRG4, activate type-1 growth factor receptors (see EGFR; MIM 131550) to initiating cell-to-cell signaling through tyrosine phosphorylation (Harari et al., 1999 [PubMed 10348342]).[supplied by OMIM, Mar 2008],

功能：
domain:ERBB receptor binding is elicited entirely by the EGF-like domain.,domain:The cytoplasmic domain may be involved in the regulation of trafficking and proteolytic processing. Regulation of the proteolytic processing involves initial intracellular domain dimerization.,function:Low affinity ligand for the ERBB4 tyrosine kinase receptor. Concomitantly recruits ERBB1 and ERBB2 coreceptors, resulting in ligand-stimulated tyrosine phosphorylation and activation of the ERBB receptors. Does not bind to the ERBB1, ERBB2 and ERBB3 receptors.,PTM:Extensive glycosylation precedes the proteolytic cleavage.,PTM:Proteolytic cleavage close to the plasma membrane on the external face leads to the release of the soluble growth factor form.,similarity:Belongs to the neuregulin family.,similarity:Contains 1 EGF-like domain.,subcellular location:Does not seem to be active.,

细胞定位：
[Pro-neuregulin-4, membrane-bound isoform]: Cell membrane ; Single-pass type I membrane protein . Does not seem to be active. .; [Neuregulin-4]: Secreted .

组织表达：
Breast,Liver,Prostate,

Empagliflozin and liraglutide ameliorate HFpEF in mice via augmenting the Erbb4 signaling pathway ACTA PHARMACOLOGICA SINICA Ni Xia-yun WB Mouse heart tissue
货号：YN2440