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HBEGF Polyclonal Antibody

货号：YN2310
应用：WB;ELISA
种属：Human;Rat;Mouse

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靶点：
HBEGF

简介：
>>Endocrine resistance;>>ErbB signaling pathway;>>GnRH signaling pathway;>>Estrogen signaling pathway;>>Parathyroid hormone synthesis, secretion and action;>>Epithelial cell signaling in Helicobacter pylori infection;>>Coronavirus disease - COVID-19;>>Proteoglycans in cancer;>>Bladder cancer

基因名称：
HBEGF DTR DTS HEGFL

蛋白名称：
Proheparin-binding EGF-like growth factor [Cleaved into: Heparin-binding EGF-like growth factor (HB-EGF) (HBEGF) (Diphtheria toxin receptor) (DT-R)]

Human Gene Id：
1839

Human Swiss Prot No：
Q99075

Mouse Swiss Prot No：
Q06186

Rat Swiss Prot No：
Q06175

免疫原：
Synthesized peptide derived from human protein . at AA range: 130-210

特异性：
HBEGF Polyclonal Antibody detects endogenous levels of protein.

组成：
Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.

来源：
Polyclonal, Rabbit,IgG

稀释：
WB 1:500-2000 ELISA 1:5000-20000

纯化工艺：
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

浓度：
1 mg/ml

储存：
-15°C to -25°C/1 year(Do not lower than -25°C)

实测条带：
22kD

背景：
function:May be involved in macrophage-mediated cellular proliferation. It is mitogenic for fibroblasts and smooth muscle but not endothelial cells. It is able to bind EGF receptors with higher affinity than EGF itself and is a far more potent mitogen for smooth muscle cells than EGF. Also acts as a diphtheria toxin receptor.,PTM:O-linked glycan attachment sites were determined by Edman degradation, O-glycanase digest suggests mucin-type glycosylation (done in HB-EGF purified from histiocytic lymphoma cell line U-937).,PTM:Several N-termini have been identified by direct sequencing. The forms with N-termini 63, 73 and 74 have been tested and found to be biologically active.,similarity:Contains 1 EGF-like domain.,subcellular location:Mature HB-EGF is released into the extracellular space and probably binds to a receptor.,

功能：
function:May be involved in macrophage-mediated cellular proliferation. It is mitogenic for fibroblasts and smooth muscle but not endothelial cells. It is able to bind EGF receptors with higher affinity than EGF itself and is a far more potent mitogen for smooth muscle cells than EGF. Also acts as a diphtheria toxin receptor.,PTM:O-linked glycan attachment sites were determined by Edman degradation, O-glycanase digest suggests mucin-type glycosylation (done in HB-EGF purified from histiocytic lymphoma cell line U-937).,PTM:Several N-termini have been identified by direct sequencing. The forms with N-termini 63, 73 and 74 have been tested and found to be biologically active.,similarity:Contains 1 EGF-like domain.,subcellular location:Mature HB-EGF is released into the extracellular space and probably binds to a receptor.,

细胞定位：
[Heparin-binding EGF-like growth factor]: Secreted, extracellular space. Mature HB-EGF is released into the extracellular space and probably binds to a receptor.; [Proheparin-binding EGF-like growth factor]: Cell membrane; Single-pass type I membrane protein.

组织表达：
Brain,Eye,Histiocytic lymphoma,Macrophage,

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货号：YN2310