Tyro3 Monoclonal Antibody
- 货号：YM0639
- 应用：WB;IF;ELISA
- 种属：Human
- 蛋白名称：
- Tyrosine-protein kinase receptor TYRO3
- 免疫原：
- Purified recombinant fragment of Tyro3 expressed in E. Coli.
- 特异性：
- Tyro3 Monoclonal Antibody detects endogenous levels of Tyro3 protein.
- 组成：
- Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
- 稀释：
- WB 1:500 - 1:2000. IF 1:200 - 1:1000. ELISA: 1:10000. Not yet tested in other applications.
- 纯化工艺：
- Affinity purification
- 储存：
- -15°C to -25°C/1 year(Do not lower than -25°C)
- 其他名称：
- TYRO3;BYK;DTK;RSE;SKY;Tyrosine-protein kinase receptor TYRO3;Tyrosine-protein kinase DTK;Tyrosine-protein kinase RSE;Tyrosine-protein kinase SKY;Tyrosine-protein kinase byk
- 背景：
- The gene is part of a 3-member transmembrane receptor kinase receptor family with a processed pseudogene distal on chromosome 15. The encoded protein is activated by the products of the growth arrest-specific gene 6 and protein S genes and is involved in controlling cell survival and proliferation, spermatogenesis, immunoregulation and phagocytosis. The encoded protein has also been identified as a cell entry factor for Ebola and Marburg viruses. [provided by RefSeq, May 2010],
- 功能：
- catalytic activity:ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.,function:May be involved in cell adhesion processes, particularly in the central nervous system. In case of filovirus infection, seems to function as a cell entry factor.,similarity:Belongs to the protein kinase superfamily. Tyr protein kinase family.,similarity:Belongs to the protein kinase superfamily. Tyr protein kinase family. AXL/UFO subfamily.,similarity:Contains 1 protein kinase domain.,similarity:Contains 2 fibronectin type-III domains.,similarity:Contains 2 Ig-like C2-type (immunoglobulin-like) domains.,subunit:Monomer and homodimer. Interacts with GAS6.,tissue specificity:Abundant in the brain and lower levels in other tissues.,
- 细胞定位：
- Cell membrane; Single-pass type I membrane protein.
- 组织表达：
- Abundant in the brain and lower levels in other tissues.
- Western Blot analysis using Tyro3 Monoclonal Antibody against truncated Tyro3 recombinant protein.
- Immunofluorescence staining of methanol-fixed MCF-7 and HepG2 cells showing membrane and cytoplasmic localization using Tyro3 Monoclonal Antibody.