ImmunoWay Biotechnology Company |抗体|病理抗体|诊断抗体

PERK Monoclonal Antibody

货号：YM0517
应用：WB;ELISA
种属：Human

产品详情
文献 ( 1 )
操作手册

靶点：
PERK

简介：
>>Mitophagy - animal;>>Autophagy - animal;>>Protein processing in endoplasmic reticulum;>>Apoptosis;>>Non-alcoholic fatty liver disease;>>Alzheimer disease;>>Parkinson disease;>>Amyotrophic lateral sclerosis;>>Prion disease;>>Pathways of neurodegeneration - multiple diseases;>>Hepatitis C;>>Measles;>>Herpes simplex virus 1 infection;>>Lipid and atherosclerosis

基因名称：
EIF2AK3

蛋白名称：
Eukaryotic translation initiation factor 2-alpha kinase 3

Human Gene Id：
9451

Human Swiss Prot No：
Q9NZJ5

Mouse Swiss Prot No：
Q9Z2B5

免疫原：
Purified recombinant fragment of human PERK expressed in E. Coli.

特异性：
PERK Monoclonal Antibody detects endogenous levels of PERK protein.

组成：
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

来源：
Monoclonal, Mouse

稀释：
WB 1:500 - 1:2000. ELISA: 1:10000. Not yet tested in other applications.

纯化工艺：
Affinity purification

储存：
-15°C to -25°C/1 year(Do not lower than -25°C)

其他名称：
EIF2AK3;PEK;PERK;Eukaryotic translation initiation factor 2-alpha kinase 3;PRKR-like endoplasmic reticulum kinase;Pancreatic eIF2-alpha kinase;HsPEK

分子量：
125kD

背景：
The protein encoded by this gene phosphorylates the alpha subunit of eukaryotic translation-initiation factor 2, leading to its inactivation, and thus to a rapid reduction of translational initiation and repression of global protein synthesis. This protein is thought to modulate mitochondrial function. It is a type I membrane protein located in the endoplasmic reticulum (ER), where it is induced by ER stress caused by malfolded proteins. Mutations in this gene are associated with Wolcott-Rallison syndrome. [provided by RefSeq, Sep 2015],

功能：
catalytic activity:ATP + a protein = ADP + a phosphoprotein.,disease:Defects in EIF2AK3 are the cause of Wolcott-Rallison syndrome (WRS) [MIM:226980]; also known as multiple epiphyseal dysplasia with early-onset diabetes mellitus. WRS is a rare autosomal recessive disorder, characterized by permanent neonatal or early infancy insulin-dependent diabetes and, at a later age, epiphyseal dysplasia, osteoporosis, growth retardation and other multisystem manifestations, such as hepatic and renal dysfunctions, mental retardation and cardiovascular abnormalities.,domain:The lumenal domain senses perturbations in protein folding in the ER, probably through reversible interaction with HSPA5/BIP.,enzyme regulation:Perturbation in protein folding in the endoplasmic reticulum (ER) promotes reversible dissociation from HSPA5/BIP and oligomerization, resulting in transautophosphorylation and kinase act

细胞定位：
Endoplasmic reticulum membrane; Single-pass type I membrane protein.

组织表达：
Ubiquitous. A high level expression is seen in secretory tissues.

Cheng, Jinbo, et al. "Vitamin D combined with resveratrol prevents cognitive decline in SAMP8 mice." Current Alzheimer Research 14.8 (2017): 820-833.
货号：YM0517