Total RFA2 Cell-Based Colorimetric ELISA Kit
- 货号：KA4267C
- 应用：ELISA
- 种属：Human;Mouse;
- 其他名称：
- Replication protein A 32 kDa subunit (RP-A p32) (Replication factor A protein 2) (RF-A protein 2) (Replication protein A 34 kDa subunit) (RP-A p34)
- 背景：
- function:Required for DNA recombination, repair and replication. The activity of RP-A is mediated by single-stranded DNA binding and protein interactions.,PTM:Phosphorylated in a cell-cycle-dependent manner (from the S phase until mitosis). Phosphorylated by ATR upon DNA damage, which promotes its translocation to nuclear foci. Can be phosphorylated in vitro by PRKDC/DNA-PK in the presence of Ku and DNA, and by CDC2.,subcellular location:Also present in PML nuclear bodies. Redistributes to discrete nuclear foci upon DNA damage.,subunit:Heterotrimer of 70, 32 and 14 kDa chains. The DNA-binding activity may reside exclusively on the 70 kDa subunit. Binds to SERTAD3/RBT1. Interacts with TIPIN.,
- 功能：
- nucleotide-excision repair, DNA damage removal, DNA metabolic process, DNA replication, DNA-dependent DNA replication, DNA repair, nucleotide-excision repair, nucleotide-excision repair, DNA gap filling, DNA catabolic process,response to DNA damage stimulus, macromolecule catabolic process, cellular response to stress, cellular macromolecule catabolic process,
- 细胞定位：
- Nucleus . Nucleus, PML body . Redistributes to discrete nuclear foci upon DNA damage in an ATR-dependent manner. .
