Total ALK Cell-Based Colorimetric ELISA Kit
- 货号：KA3992C
- 应用：ELISA
- 种属：Human;Mouse
- 其他名称：
- ALK tyrosine kinase receptor (EC 2.7.10.1) (Anaplastic lymphoma kinase) (CD antigen CD246)
- 背景：
- catalytic activity:ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.,disease:A chromosomal aberration involving ALK is associated with anaplastic large-cell lymphoma (ALCL). Translocation t(2;17)(p23;q25) with ALO17.,disease:A chromosomal aberration involving ALK is associated with inflammatory myofibroblastic tumors (IMTs). Translocation t(2;11)(p23;p15) with CARS; translocation t(2;4)(p23;q21) with SEC31A.,disease:A chromosomal aberration involving ALK is found in a form of non-Hodgkin lymphoma. Translocation t(2;5)(p23;q35) with NPM1. The resulting chimeric NPM1-ALK protein homodimerize and the kinase becomes constitutively activated. The constitutively active fusion proteins are responsible for 5-10% of non-Hodgkin lymphomas.,function:Orphan receptor with a tyrosine-protein kinase activity. Appears to play an important role in the normal development and function of the nervous system. Phosphorylates almost exclusively at the first tyrosine of the Y-x-x-x-Y-Y motif.,PTM:N-glycosylated.,similarity:Belongs to the protein kinase superfamily. Tyr protein kinase family. Insulin receptor subfamily.,similarity:Contains 1 LDL-receptor class A domain.,similarity:Contains 1 protein kinase domain.,similarity:Contains 2 MAM domains.,subunit:Homodimer. When bound to ligand.,tissue specificity:Expressed in brain and CNS. Also expressed in the small intestine and testis, but not in normal lymphoid cells.,
- 功能：
- protein amino acid phosphorylation, protein amino acid glycosylation, protein amino acid N-linked glycosylation,phosphorus metabolic process, phosphate metabolic process, cell surface receptor linked signal transduction, enzyme linked receptor protein signaling pathway, transmembrane receptor protein tyrosine kinase signaling pathway,glycoprotein metabolic process, glycoprotein biosynthetic process, phosphorylation, biopolymer glycosylation,glycosylation,
- 细胞定位：
- Cell membrane ; Single-pass type I membrane protein . Membrane attachment is essential for promotion of neuron-like differentiation and cell proliferation arrest through specific activation of the MAP kinase pathway. .
- 组织表达：
- Expressed in brain and CNS. Also expressed in the small intestine and testis, but not in normal lymphoid cells.
